Literature summary for 1.3.1.72 extracted from

Mirza, R.; Hayasaka, S.; Takagishi, Y.; Kambe, F.; Ohmori, S.; Maki, K.; Yamamoto, M.; Murakami, K.; Kaji, T.; Zadworny, D.; Murata, Y.; Seo, H.
DHCR24 gene knockout mice demonstrate lethal dermopathy with differentiation and maturation defects in the epidermis (2006), J. Invest. Dermatol., 126, 638-647.

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Application

Application	Comment	Organism
medicine	DHCR24 plays crucial role for skin development and its proper function	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	DHCR24 knockout mice, development of the epidermis, especially keratinization, is impaired, altered expression of filaggrin, loricrin, and involcrin, transepidermal water loss is markedly increased, impaired skin barrier function	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q8VCH6	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
epidermis	abundantly expressed throughout the epidermis except for the stratum corneum and in hair follicles	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
desmosterol + NADPH	-	Mus musculus	cholesterol + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
3beta-hydroxysterol-delta24 reductase	-	Mus musculus
DHCR24	-	Mus musculus

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Release 2023.1 (January 2023)