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Literature summary for 1.3.1.70 extracted from

  • Bennati, A.M.; Castelli, M.; Della Fazia, M.A.; Beccari, T.; Caruso, D.; Servillo, G.; Roberti, R.
    Sterol dependent regulation of human TM7SF2 gene expression: role of the encoded 3beta-hydroxysterol DELTA14-reductase in human cholesterol biosynthesis (2006), Biochim. Biophys. Acta, 1761, 677-685.
    View publication on PubMed
Search for more literature for 1.3.1.70

Cloned(Commentary)

Cloned (Comment) Organism
expression of LBR in COS-1 cells Homo sapiens
TM7SF2 expression in COS-1 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum TM7SF2 Homo sapiens 5783
-
nuclear membrane inner nuclear membrane, LBR Homo sapiens 31965
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens C14SR is encoded by the TM7SF2 gene. TM7SF2 but not LBR, gene expression is regulated by cell sterol levels in HepG2 (human) and H-35 (rat) hepatoma cells. Primary role of C14SR in human cholesterol biosynthesis ?
-
 ?
additional information Homo sapiens role of LBR in the cholesterol biosynthesis pathway is unclear ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland TM7SF2 shows the highest mRNA expression Homo sapiens
-
adrenal gland LBR Homo sapiens
-
bone marrow highest expression of LBR Homo sapiens
-
brain foetal and adult, LBR Homo sapiens
-
colon LBR Homo sapiens
-
heart in foetal heart the expression is much lower then in the adult heart, TM7SF2 Homo sapiens
-
heart foetal and adult Homo sapiens
-
kidney TM7SF2 Homo sapiens
-
kidney foetal and adult, LBR Homo sapiens
-
leukocyte peripheral blood leukocyte, LBR Homo sapiens
-
liver TM7SF2 Homo sapiens
-
liver foetal and adult, LBR Homo sapiens
-
lung foetal and adult, LBR Homo sapiens
-
lymph node TM7SF2 Homo sapiens
-
lymph node LBR Homo sapiens
-
ovary LBR Homo sapiens
-
pancreas TM7SF2 Homo sapiens
-
pancreas LBR Homo sapiens
-
placenta LBR Homo sapiens
-
prostate LBR Homo sapiens
-
prostate gland TM7SF2 Homo sapiens
-
skeletal muscle LBR Homo sapiens
-
spleen foetal and adult, LBR Homo sapiens
-
spleen LBR Homo sapiens
-
stomach TM7SF2 Homo sapiens
-
stomach LBR Homo sapiens
-
testis TM7SF2 Homo sapiens
-
testis LBR Homo sapiens
-
thymus in foetal thymus expression is much higher than in the adult thymus, TM7SF2 Homo sapiens
-
thymus foetal and adult, LBR Homo sapiens
-
thyroid gland TM7SF2 Homo sapiens
-
thyroid gland LBR Homo sapiens
-
uterus LBR Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5alpha-cholesta-8,14-dien-3beta-ol + NADPH + H+ TM7SF2 Homo sapiens 5alpha-cholesta-8-en-3beta-ol + NADP+
-
 ?
5alpha-cholesta-8,14-dien-3beta-ol + NADPH + H+ LBR Homo sapiens 5alpha-cholesta-8-en-3beta-ol + NADP+
-
 ?
additional information C14SR is encoded by the TM7SF2 gene. TM7SF2 but not LBR, gene expression is regulated by cell sterol levels in HepG2 (human) and H-35 (rat) hepatoma cells. Primary role of C14SR in human cholesterol biosynthesis Homo sapiens ?
-
 ?
additional information role of LBR in the cholesterol biosynthesis pathway is unclear Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
3beta-hydroxysterol DELTA14-reductase besides the endoplasmic reticulum 3beta-hydroxysterol DELTA14-reductase (C14SR) encoded by TM7SF2 gene, the lamin B receptor (LBR) of the inner nuclear membrane possesses 3beta-hydroxysterol DELTA14-reductase activity Homo sapiens
C14SR
-
 Homo sapiens
lamin B receptor
-
 Homo sapiens
LBR
-
 Homo sapiens