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Literature summary for 1.3.1.70 extracted from

  • Jia, N.; Arthington-Skaggs, B.; Lee, W.; Pierson, C.A.; Lees, N.D.; Eckstein, J.; Barbuch, R.; Bard, M.
    Candida albicans sterol C-14 reductase, encoded by the ERG24 gene, as a potential antifungal target site (2002), Antimicrob. Agents Chemother., 46, 947-957.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
pharmacology enzyme is a potential antifungal target site, development of antifungal compounds Candida albicans

Cloned(Commentary)

Cloned (Comment) Organism
gene erg24, DNA and amino acid sequence determination, subcloning in Escherichia coli strain DH5alpha, complementation of the enzyme-deficient Saccharomyces cerevisiae erg24 mutant strain AP2 Candida albicans

Protein Variants

Protein Variants Comment Organism
additional information erg24 gene disruption mutant strains, i.e. strain NJ25, NJ50, NJ51, and NJ55, show growth, but altered phenotypes, e.g. increased sensitivity against an allylamine antifungal compound, overview Candida albicans

Inhibitors

Inhibitors Comment Organism Structure
brefeldin inhibition of growth of mutant strains NJ25, NJ50, NJ51, and NJ55, not of wild-type strain and mutant NJ25, overview Candida albicans
Ca2+ slight inhibition of growth of the wild-type strain, increased inhibition of growth of erg24 mutant strains Candida albicans
cerulenin inhibition of growth of mutant strains NJ25, NJ50, NJ51, and NJ55, not of wild-type strain and mutant NJ25, overview Candida albicans
clotrimazole inhibition of growth of wild-type and mutant strains NJ25, NJ50, NJ51, and NJ55, overview Candida albicans
cycloheximide inhibition of growth of mutant strains NJ25, NJ50, NJ51, and NJ55, not of wild-type strain and mutant NJ25, overview Candida albicans
fenpropimorph inhibition of growth of wild-type and mutant strains NJ25, NJ50, NJ51, and NJ55, overview Candida albicans
fluconazole inhibition of growth of wild-type and mutant strain NJ25, only slightly of mutant strains NJ50, NJ51, and NJ55, overview Candida albicans
fluphenazine inhibition of growth of mutant strains NJ25, NJ50, NJ51, and NJ55, not of wild-type strain and mutant NJ25, overview Candida albicans
itraconazole inhibition of growth of wild-type and mutant strain NJ25, only slightly of mutant strains NJ50, NJ51, and NJ55, overview Candida albicans
ketoconazole inhibition of growth of wild-type and mutant strains NJ25, NJ50, NJ51, and NJ55, overview Candida albicans
Nystatin inhibition of growth of wild-type and mutant strain NJ25, not of mutants strains NJ50, NJ51, and NJ55, overview Candida albicans
terbinafine inhibition of growth of mutant strains NJ25, NJ50, NJ51, and NJ55, not of wild-type strain and mutant NJ25, overview Candida albicans
tridemorph inhibition of growth of wild-type and mutant strains NJ25, NJ50, NJ51, and NJ55, overview Candida albicans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Candida albicans enzyme plays a key role in sterol biosynthesis, sterol content in vivo ?
-
?

Organism

Organism UniProt Comment Textmining
Candida albicans
-
gene erg24
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information growth of wild-type and disruption mutant strains with various media and temperature conditions, overview Candida albicans
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme plays a key role in sterol biosynthesis, sterol content in vivo Candida albicans ?
-
?

Synonyms

Synonyms Comment Organism
sterol C-14 reductase
-
Candida albicans