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Literature summary for 1.3.1.6 extracted from

  • Merlino, A.; Vieites, M.; Gambino, D.; Coitino, E.L.
    Homology modeling of T. cruzi and L. major NADH-dependent fumarate reductases: ligand docking, molecular dynamics validation, and insights on their binding modes (2014), J. Mol. Graph. Model., 48, 47-59.
    View publication on PubMed
Search for more literature for 1.3.1.6

Inhibitors

Inhibitors Comment Organism Structure
licochalcone A
-
 Leishmania major
licochalcone A
-
 Trypanosoma cruzi
Pd(2-mercaptopyridine N-oxide)2
-
 Leishmania major
Pd(2-mercaptopyridine N-oxide)2
-
 Trypanosoma cruzi
Pt(2-mercaptopyridine N-oxide)2
-
 Leishmania major
Pt(2-mercaptopyridine N-oxide)2
-
 Trypanosoma cruzi
VO(2-mercaptopyridine N-oxide)2
-
 Leishmania major
VO(2-mercaptopyridine N-oxide)2
-
 Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fumarate + NADH + H+ Trypanosoma cruzi
-
 succinate + NAD+
-
 ir
fumarate + NADH + H+ Leishmania major
-
 succinate + NAD+
-
 ir
fumarate + NADH + H+ Trypanosoma cruzi CL Brener
-
 succinate + NAD+
-
 ir

Organism

Organism UniProt Comment Textmining
Leishmania major E9AEQ8
-
-
Trypanosoma cruzi Q4CYX1
-
-
Trypanosoma cruzi CL Brener Q4CYX1
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fumarate + NADH + H+
-
 Trypanosoma cruzi succinate + NAD+
-
 ir
fumarate + NADH + H+
-
 Leishmania major succinate + NAD+
-
 ir
fumarate + NADH + H+
-
 Trypanosoma cruzi CL Brener succinate + NAD+
-
 ir

Synonyms

Synonyms Comment Organism
NADH-dependent fumarate reductase
-
 Trypanosoma cruzi
NADH-dependent fumarate reductase
-
 Leishmania major

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Trypanosoma cruzi
NADH
-
 Leishmania major

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0132
-
 licochalcone A pH and temperature not specified in the publication Leishmania major
0.0793
-
 Pd(2-mercaptopyridine N-oxide)2 pH and temperature not specified in the publication Trypanosoma cruzi
0.101
-
 Pt(2-mercaptopyridine N-oxide)2 pH and temperature not specified in the publication Trypanosoma cruzi
0.109
-
 VO(2-mercaptopyridine N-oxide)2 pH and temperature not specified in the publication Trypanosoma cruzi
0.111
-
 VO(2-mercaptopyridine N-oxide)2 pH and temperature not specified in the publication Leishmania major
0.122
-
 Pd(2-mercaptopyridine N-oxide)2 pH and temperature not specified in the publication Leishmania major
0.131
-
 Pt(2-mercaptopyridine N-oxide)2 pH and temperature not specified in the publication Leishmania major