Application | Comment | Organism |
---|---|---|
medicine | the enzyme is a target in anticancer therapy | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
pyrvinium pamoate | an anthelmintic drug, has an anticancer effect within tumor-mimicking microenvironments, biological mechanism of pyrvinium is the inhibition of the NADH-fumarate reductase system. Under normal conditions, pyrvinium pamoate activates complex II activity and inhibits complex I activity. Pyrvinium pamoate activates the mitochondrial respiratory chain via complex II, despite inhibiting complex I. In cancer cells under hypoxic and glucose-deprived conditions, the activation of SQR by pyrvinium pamoate disappeared and NADH-fumarate reductase activity is inhibited. Pyrvinium pamoate becomes cytotoxic to cancer cells under tumor microenvironmental conditions | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinate + NAD+ | Homo sapiens | - |
fumarate + NADH + H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pancreatic cancer cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinate + NAD+ | - |
Homo sapiens | fumarate + NADH + H+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
NADH-FR | - |
Homo sapiens |
NADH-fumarate reductase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens | |
NADH | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is part of the NADH-fumarate reductase system in cancer cell microenvironments, with deficiencies of critical nutrients and hypoxia, where it is important for maintaining mitochondrial energy metabolism, overview. The NADH-fumarate reductase system is the function of complex II | Homo sapiens |