Application | Comment | Organism |
---|---|---|
drug development | lack of NADH-fumarate reductase in mammalian cells provides an interesting target against Chagas disease | Trypanosoma cruzi |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Pd-(pyridine-2-thiol N-oxide)2 | inhibitory effect of metal-pyridine-2-thiol N-oxide complexes, marked increase is obeserved in the inhibitory effect with respect to that of the free ligand, inhibition in a dose-dependent manner, a clear relief of the growth inhibition produced by the metal-mpo complex is observed in the presence of 5 mM succinate | Trypanosoma cruzi | |
Pt-(pyridine-2-thiol N-oxide)2 | inhibitory effect of metal-pyridine-2-thiol N-oxide complexes, inhibition observed 2 is similar to that obtained with the ligand alone, a clear relief of the growth inhibition produced by the metal-mpo complex is observed in the presence of 5 mM succinate | Trypanosoma cruzi | |
pyridine-2-thiol N-oxide | 2-mercaptopyridine N-oxide (mpo) is a bioactive ligand with a potential as antitrypanosomal agent | Trypanosoma cruzi | |
sodium pyridine-2-thiol N-oxide | inhibitory effect of the sodium salt | Trypanosoma cruzi |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
fumarate + NADH + H+ | Trypanosoma cruzi | parasite-specific enzyme, succinate is one of the main respiratory substrates and is therefore required by the parasite for energy production | succinate + NAD+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma cruzi | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epimastigote | - |
Trypanosoma cruzi | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
fumarate + NADH + H+ | parasite-specific enzyme, succinate is one of the main respiratory substrates and is therefore required by the parasite for energy production | Trypanosoma cruzi | succinate + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NADH-fumarate reductase | - |
Trypanosoma cruzi |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Trypanosoma cruzi |