Application | Comment | Organism |
---|---|---|
medicine | aurones and auronols can be used as antiprotozoal compounds because the kill intracellularly persisting amastigozyte of Leishmania major by inhibiting respiratory function of parasite mitochondria | Leishmania major |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2',6-dihydroxy-2-[phenylmethylene]-3(2H)-benzofuran-3-one | - |
Leishmania major | |
3',4',6-trihydroxy-2-[phenylmethylene]-3(2H)-benzofuran-3-one | - |
Leishmania major | |
3',6-dihydroxy-2-[phenylmethylene]-3(2H)-benzofuran-3-one | - |
Leishmania major | |
4',6-dihydroxy-2-[phenylmethylene]-3(2H)-benzofuran-3-one | - |
Leishmania major | |
4,6,3'-hydroxy-4'-methoxy-2-[phenylhydroxymethylene]-3(2H)-benzofuran-3-one | - |
Leishmania major | |
4,6,4'-hydroxy-3'-methoxy-2-[phenylhydroxymethylene]-3(2H)-benzofuran-3-one | - |
Leishmania major | |
4,6,4'-triacetyl-3',5'-dimethoxy-2-[phenylhydroxymethylene]-3(2H)-benzofuran-3-one | i.e. bracteintriacetate | Leishmania major | |
4,6-dihydroxy-2-[phenylhydroxymethylene]-3(2H)-benzofuran-3-ol | - |
Leishmania major | |
6-benzoyl-2-[phenylhydroxymethylene]-3(2H)-benzofuran-3-ol | - |
Leishmania major | |
6-hydroxy-2-[(2,3,4-trihydroxyphenyl)-methylene]-3(2H)-benzofuran-3-one-5-beta-D-glucopyranoside | i.e. bractein | Leishmania major | |
6-hydroxy-2-[phenylmethylene]-3(2H)-benzofuran-3-one | - |
Leishmania major | |
6-hydroxy-3',4'-dimethoxy-2-[phenylhydroxymethylene]-3(2H)-benzofuran-3-one | - |
Leishmania major | |
6-hydroxy-benzofuran-3-one | - |
Leishmania major | |
6-methoxy-2-[phenylmethylene]-3(2H)-benzofuran-3-one | - |
Leishmania major | |
additional information | inhibitory potency of aurones and auronols, overview | Leishmania major |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Leishmania major | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
fumarate + NADH + H+ | Leishmania major | - |
succinate + NAD+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania major | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partially, preparation of the mitochondrial fraction | Leishmania major |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
fumarate + NADH + H+ | - |
Leishmania major | succinate + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FRD | - |
Leishmania major |
fumarate reductase | - |
Leishmania major |
NADH-FRD | - |
Leishmania major |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Leishmania major |