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Literature summary for 1.3.1.6 extracted from

  • Kayser, O.; Chen, M.; Kharazmi, A.; Kiderlen, A.F.
    Aurones interfere with Leishmania major mitochondrial fumarate reductase (2002), Z. Naturforsch. C, 57c, 717-720.
No PubMed abstract available
Search for more literature for 1.3.1.6

Application

Application Comment Organism
medicine aurones and auronols can be used as antiprotozoal compounds because the kill intracellularly persisting amastigozyte of Leishmania major by inhibiting respiratory function of parasite mitochondria Leishmania major

Inhibitors

Inhibitors Comment Organism Structure
2',6-dihydroxy-2-[phenylmethylene]-3(2H)-benzofuran-3-one
-
 Leishmania major
3',4',6-trihydroxy-2-[phenylmethylene]-3(2H)-benzofuran-3-one
-
 Leishmania major
3',6-dihydroxy-2-[phenylmethylene]-3(2H)-benzofuran-3-one
-
 Leishmania major
4',6-dihydroxy-2-[phenylmethylene]-3(2H)-benzofuran-3-one
-
 Leishmania major
4,6,3'-hydroxy-4'-methoxy-2-[phenylhydroxymethylene]-3(2H)-benzofuran-3-one
-
 Leishmania major
4,6,4'-hydroxy-3'-methoxy-2-[phenylhydroxymethylene]-3(2H)-benzofuran-3-one
-
 Leishmania major
4,6,4'-triacetyl-3',5'-dimethoxy-2-[phenylhydroxymethylene]-3(2H)-benzofuran-3-one i.e. bracteintriacetate Leishmania major
4,6-dihydroxy-2-[phenylhydroxymethylene]-3(2H)-benzofuran-3-ol
-
 Leishmania major
6-benzoyl-2-[phenylhydroxymethylene]-3(2H)-benzofuran-3-ol
-
 Leishmania major
6-hydroxy-2-[(2,3,4-trihydroxyphenyl)-methylene]-3(2H)-benzofuran-3-one-5-beta-D-glucopyranoside i.e. bractein Leishmania major
6-hydroxy-2-[phenylmethylene]-3(2H)-benzofuran-3-one
-
 Leishmania major
6-hydroxy-3',4'-dimethoxy-2-[phenylhydroxymethylene]-3(2H)-benzofuran-3-one
-
 Leishmania major
6-hydroxy-benzofuran-3-one
-
 Leishmania major
6-methoxy-2-[phenylmethylene]-3(2H)-benzofuran-3-one
-
 Leishmania major
additional information inhibitory potency of aurones and auronols, overview Leishmania major

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Leishmania major 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fumarate + NADH + H+ Leishmania major
-
 succinate + NAD+
-
 ?

Organism

Organism UniProt Comment Textmining
Leishmania major
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partially, preparation of the mitochondrial fraction Leishmania major

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fumarate + NADH + H+
-
 Leishmania major succinate + NAD+
-
 ?

Synonyms

Synonyms Comment Organism
FRD
-
 Leishmania major
fumarate reductase
-
 Leishmania major
NADH-FRD
-
 Leishmania major

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Leishmania major