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Literature summary for 1.3.1.6 extracted from
- Characterization of the NADH dehydrogenase and fumarate reductase of Fibrobacter succinogenes subsp. succinogenes S85 (1994), Arch. Microbiol., 162, 329-334.
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| KCl | can repace for NaCl | Fibrobacter succinogenes |  |
| NaCl | required for full activity, about 10fold activation at 150 mM | Fibrobacter succinogenes | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-n-heptyl-4-hydroxyquinoline-N-oxide | strong inhibitor | Fibrobacter succinogenes | |
| rotenone | - |
Fibrobacter succinogenes | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Fibrobacter succinogenes | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| fumarate + NADH + H+ | Fibrobacter succinogenes | realizes formation of succinate from oxalacetate | succinate + NAD+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Fibrobacter succinogenes | - |
- |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.2 | 0.4 | - |
Fibrobacter succinogenes |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| fumarate + NADH + H+ | - |
Fibrobacter succinogenes | succinate + NAD+ | - |
? | |
| fumarate + NADH + H+ | realizes formation of succinate from oxalacetate | Fibrobacter succinogenes | succinate + NAD+ | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
in presence of NaCl, without NaCl maximum activity below pH 5 | Fibrobacter succinogenes |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 7 | in presence of NaCl | Fibrobacter succinogenes |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | - |
Fibrobacter succinogenes | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0006 | - |
2-n-heptyl-4-hydroxyquinoline-N-oxide | - |
Fibrobacter succinogenes | |
| 0.001 | - |
rotenone | - |
Fibrobacter succinogenes | |
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