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Literature summary for 1.3.1.48 extracted from

  • Mesa, J.; Alsina, C.; Oppermann, U.; Pares, X.; Farres, J.; Porte, S.
    Human prostaglandin reductase 1 (PGR1) Substrate specificity, inhibitor analysis and site-directed mutagenesis (2015), Chem. Biol. Interact., 234, 105-113 .
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
three-dimensional structure analysis of the human enzyme, PDB ID 2Y05 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information evaluation of non-steroidal anti-inflammatory drugs (NSAIDs) as enzyme potential inhibitors Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
additional information the isozyme is zinc-independent Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
11alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ Homo sapiens
-
(13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate + NAD(P)H + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P15428
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH + H+
-
Homo sapiens 11alpha-hydroxy-9,15-dioxoprostanoate + NADP+
-
?
11alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+
-
Homo sapiens (13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate + NAD(P)H + H+
-
?
additional information PGR1, which catalyzes the NADPH-dependent reduction of the alpha,beta-double bond of aliphatic and aromatic aldehydes and ketones, and 15-keto-prostaglandins. PGR1 also shows low activity in the oxidation of leukotriene B4. The best substrates in terms of kcat/Km are 15-keto-prostaglandins, trans-3-nonen-2-one, and trans-2-decenal. Molecular docking simulations, role of Arg56 and Tyr245 in 15-keto-prostaglandin binding, overview Homo sapiens ?
-
?
trans-2-decenal + NADPH + H+
-
Homo sapiens decanal + NADP+
-
?
trans-3-nonen-2-one + NADPH + H+
-
Homo sapiens ? + NADP+
-
?

Synonyms

Synonyms Comment Organism
15-keto-PG reductase
-
Homo sapiens
leukotriene B4 dehydrogenase
-
Homo sapiens
PG reductase
-
Homo sapiens
PGR1
-
Homo sapiens
prostaglandin 13-reductase
-
Homo sapiens
prostaglandin reductase 1
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens

General Information

General Information Comment Organism
evolution the three human PG reductases are zinc-independent members of the medium-chain dehydrogenase/reductase (MDR) superfamily Homo sapiens
metabolism prostaglandins are lipid compounds derived from arachidonic acid by the action of cyclooxygenases, acting locally as messenger molecules in a wide variety of physiological processes, such as inflammation, cell survival, apoptosis, smooth muscle contraction, adipocyte differentiation, vasodilation and platelet aggregation inhibition. In the inactivating pathway of prostaglandins, the first metabolic intermediates are 15-keto-prostaglandins, which are further converted into 13,14-dihydro-15-keto-prostaglandins by different enzymes having 15-keto-prostaglandin reductase activity Homo sapiens