Crystallization (Comment) | Organism |
---|---|
three-dimensional structure analysis of the human enzyme, PDB ID 2Y05 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | evaluation of non-steroidal anti-inflammatory drugs (NSAIDs) as enzyme potential inhibitors | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | the isozyme is zinc-independent | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
11alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ | Homo sapiens | - |
(13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate + NAD(P)H + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P15428 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH + H+ | - |
Homo sapiens | 11alpha-hydroxy-9,15-dioxoprostanoate + NADP+ | - |
? | |
11alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ | - |
Homo sapiens | (13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate + NAD(P)H + H+ | - |
? | |
additional information | PGR1, which catalyzes the NADPH-dependent reduction of the alpha,beta-double bond of aliphatic and aromatic aldehydes and ketones, and 15-keto-prostaglandins. PGR1 also shows low activity in the oxidation of leukotriene B4. The best substrates in terms of kcat/Km are 15-keto-prostaglandins, trans-3-nonen-2-one, and trans-2-decenal. Molecular docking simulations, role of Arg56 and Tyr245 in 15-keto-prostaglandin binding, overview | Homo sapiens | ? | - |
? | |
trans-2-decenal + NADPH + H+ | - |
Homo sapiens | decanal + NADP+ | - |
? | |
trans-3-nonen-2-one + NADPH + H+ | - |
Homo sapiens | ? + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
15-keto-PG reductase | - |
Homo sapiens |
leukotriene B4 dehydrogenase | - |
Homo sapiens |
PG reductase | - |
Homo sapiens |
PGR1 | - |
Homo sapiens |
prostaglandin 13-reductase | - |
Homo sapiens |
prostaglandin reductase 1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
evolution | the three human PG reductases are zinc-independent members of the medium-chain dehydrogenase/reductase (MDR) superfamily | Homo sapiens |
metabolism | prostaglandins are lipid compounds derived from arachidonic acid by the action of cyclooxygenases, acting locally as messenger molecules in a wide variety of physiological processes, such as inflammation, cell survival, apoptosis, smooth muscle contraction, adipocyte differentiation, vasodilation and platelet aggregation inhibition. In the inactivating pathway of prostaglandins, the first metabolic intermediates are 15-keto-prostaglandins, which are further converted into 13,14-dihydro-15-keto-prostaglandins by different enzymes having 15-keto-prostaglandin reductase activity | Homo sapiens |