Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | NADH inhibits mitochondrial beta-oxidation, while acetyl-CoA has no effect | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics of oleoyl-CoA degradation in mitochondrial protein extract | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | 3,5-cis-tetradecadienoyl-CoA is also converted by the reductase pathway of beta-oxidation in mitochondria via 2,4-cis-didehydrotetradecadienoyl-CoA | ? | - |
? | |
trans-trans-2,4-hexadecadienoyl-CoA + NADPH | Rattus norvegicus | step in the beta-oxidation of oleoyl-CoA via 2-trans-5-cis-tetradecadienoyl-CoA in mitochondria via the reductase-dependent pathway, enzyme is not involved in the isomerase-dependent pathway, overview | trans-2-hexadecenoyl-CoA + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partial, solubilization of enzyme using Triton X-100 from heart mitochondria | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,4-cis-tetradecadienoyl-CoA + NADPH | low activity | Rattus norvegicus | 2-cis-dehydroacyl-CoA + NADP+ | - |
? | |
2,4-trans-tetradecadienoyl-CoA + NADPH | - |
Rattus norvegicus | 2-trans-dehydroacyl-CoA + NADP+ | - |
? | |
additional information | 3,5-cis-tetradecadienoyl-CoA is also converted by the reductase pathway of beta-oxidation in mitochondria via 2,4-cis-didehydrotetradecadienoyl-CoA | Rattus norvegicus | ? | - |
? | |
trans-trans-2,4-hexadecadienoyl-CoA + NADPH | step in the beta-oxidation of oleoyl-CoA via 2-trans-5-cis-tetradecadienoyl-CoA in mitochondria via the reductase-dependent pathway, enzyme is not involved in the isomerase-dependent pathway, overview | Rattus norvegicus | trans-2-hexadecenoyl-CoA + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
2,4-dienoyl-CoA reductase | - |
Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | absolutely dependent on | Rattus norvegicus |