Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0057 | - |
4-androstene-3,17-dione | isoform AKR1D4L, pH 7, 37°C | Mus musculus | |
0.0071 | - |
cortisol | isoform AKR1D4L, pH 7, 37°C | Mus musculus | |
0.008 | - |
4-androstene-3,17-dione | isoform AKR1D4S, pH 7, 37°C | Mus musculus | |
0.0114 | - |
cortisol | isoform AKR1D4S, pH 7, 37°C | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8VCX1 | - |
- |
Purification (Comment) | Organism |
---|---|
recombinant protein | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | expression of total AKR1D4 transcripts is 100fold higher in liver versus testis | Mus musculus | - |
testis | expression of total AKR1D4 transcripts is 100fold higher in liver versus testis | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-androstene-3,17-dione + NADPH + H+ | - |
Mus musculus | 5beta-androstan-3,15-dione + 3alpha-hydroxy-5beta-androstan-17-one + NADP+ | - |
? | |
cortisol + NADPH + H+ | - |
Mus musculus | 11beta,17,21-trihydroxy-5beta-pregnane-3,20-dione + NADP+ | - |
? | |
progesterone + NADPH + H+ | - |
Mus musculus | 5beta-pregnane-3,20-dione + NADP+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | there exists a long-form, with an 18 amino-acid extension at the N-terminus (AKR1D4L) and a short-form (AKR1D4S) | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
AKR1D1 | - |
Mus musculus |
AKR1D4 | - |
Mus musculus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.05 | - |
4-androstene-3,17-dione | isoform AKR1D4L, pH 7, 37°C | Mus musculus | |
0.08 | - |
cortisol | isoform AKR1D4L, pH 7, 37°C | Mus musculus | |
0.09 | - |
4-androstene-3,17-dione | isoform AKR1D4S, pH 7, 37°C | Mus musculus | |
0.13 | - |
cortisol | isoform AKR1D4S, pH 7, 37°C | Mus musculus |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.93 | - |
4-androstene-3,17-dione | isoform AKR1D4L, pH 7, 37°C | Mus musculus | |
1 | - |
4-androstene-3,17-dione | isoform AKR1D4S, pH 7, 37°C | Mus musculus | |
10.5 | - |
cortisol | isoform AKR1D4S, pH 7, 37°C | Mus musculus | |
13 | - |
cortisol | isoform AKR1D4L, pH 7, 37°C | Mus musculus |