Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-benzoylbenzoic acid | - |
Homo sapiens | |
chenodeoxycholic acid | - |
Homo sapiens | |
indomethacin | - |
Homo sapiens | |
Mefenamic acid | - |
Homo sapiens | |
additional information | substrate inhibition is observed with C18 to C21 steroids provided that the C11 position is unsubstituted | Homo sapiens | |
Ursodeoxycholic acid | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0003 | - |
cholestenone | pH 6.0, 37°C | Homo sapiens | |
0.0008 | - |
4-cholesten-7alpha-ol-3-one | pH 6.0, 37°C | Homo sapiens | |
0.0009 | - |
4-androstene-3,17-dione | pH 6.0, 37°C | Homo sapiens | |
0.0022 | - |
corticosterone | pH 6.0, 37°C | Homo sapiens | |
0.0025 | - |
aldosterone | pH 6.0, 37°C | Homo sapiens | |
0.0027 | - |
testosterone | pH 6.0, 37°C | Homo sapiens | |
0.0029 | - |
Epitestosterone | pH 6.0, 37°C | Homo sapiens | |
0.003 | - |
4-estren-17beta-ol-3-one | pH 6.0, 37°C | Homo sapiens | |
0.0032 | - |
1,4-androstadien-17beta-ol-3-one | pH 6.0, 37°C | Homo sapiens | |
0.0131 | - |
cortisol | pH 6.0, 37°C | Homo sapiens | |
0.0151 | - |
cortisone | pH 6.0, 37°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,4-androstadien-17beta-ol-3-one + NADPH + H+ | - |
Homo sapiens | ? | - |
? | |
4-androstene-3,17-dione + NADPH + H+ | - |
Homo sapiens | ? | - |
? | |
4-cholesten-7alpha-ol-3-one + NADPH + H+ | - |
Homo sapiens | ? | - |
? | |
4-estren-17beta-ol-3-one + NADPH + H+ | - |
Homo sapiens | ? | - |
? | |
aldosterone + NADPH + H+ | - |
Homo sapiens | ? | - |
? | |
cholestenone + NADPH + H+ | - |
Homo sapiens | ? | - |
? | |
corticosterone + NADPH + H+ | - |
Homo sapiens | ? | - |
? | |
cortisol + NADPH + H+ | - |
Homo sapiens | ? | - |
? | |
cortisone + NADPH + H+ | - |
Homo sapiens | ? | - |
? | |
epitestosterone + NADPH + H+ | - |
Homo sapiens | ? | - |
? | |
additional information | substrate specificity of homogeneous human recombinant AKR1D1 using C18, C19, C21, and C27 DELTA4-ketosteroids, AKR1D1 proficiently reduces all the steroids tested at physiological pH, overview | Homo sapiens | ? | - |
? | |
testosterone + NADPH + H+ | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AKR1D1 | - |
Homo sapiens |
aldo-keto reductase 1D1 | - |
Homo sapiens |
steroid 5beta-reductase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.01 | - |
cholestenone | pH 6.0, 37°C | Homo sapiens | |
0.032 | - |
corticosterone | pH 6.0, 37°C | Homo sapiens | |
0.033 | - |
4-cholesten-7alpha-ol-3-one | pH 6.0, 37°C | Homo sapiens | |
0.035 | - |
1,4-androstadien-17beta-ol-3-one | pH 6.0, 37°C | Homo sapiens | |
0.045 | - |
cortisol | pH 6.0, 37°C | Homo sapiens | |
0.045 | - |
4-estren-17beta-ol-3-one | pH 6.0, 37°C | Homo sapiens | |
0.1 | - |
4-androstene-3,17-dione | pH 6.0, 37°C | Homo sapiens | |
0.1 | - |
Epitestosterone | pH 6.0, 37°C | Homo sapiens | |
0.14 | - |
testosterone | pH 6.0, 37°C | Homo sapiens | |
0.15 | - |
aldosterone | pH 6.0, 37°C | Homo sapiens | |
0.195 | - |
cortisone | pH 6.0, 37°C | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | - |
- |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | existence of a small alternative substrate binding pocket, structure-activity relationship, overview | Homo sapiens |
physiological function | human steroid 5beta-reductase, i.e. aldo-keto reductase 1D1, catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of DELTA4-ketosteroids to yield an A/B cis-ring junction. This cis configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. AKR1D1 is the only enzyme necessary for all the 5-steroid metabolites present in humans | Homo sapiens |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.77 | - |
4-androstene-3,17-dione | pH 6.0, 37°C | Homo sapiens | |
3.44 | - |
cortisol | pH 6.0, 37°C | Homo sapiens | |
10.94 | - |
1,4-androstadien-17beta-ol-3-one | pH 6.0, 37°C | Homo sapiens | |
12.91 | - |
cortisone | pH 6.0, 37°C | Homo sapiens | |
14.54 | - |
corticosterone | pH 6.0, 37°C | Homo sapiens | |
15 | - |
4-estren-17beta-ol-3-one | pH 6.0, 37°C | Homo sapiens | |
33.33 | - |
cholestenone | pH 6.0, 37°C | Homo sapiens | |
34.48 | - |
Epitestosterone | pH 6.0, 37°C | Homo sapiens | |
41.25 | - |
4-cholesten-7alpha-ol-3-one | pH 6.0, 37°C | Homo sapiens | |
51.85 | - |
testosterone | pH 6.0, 37°C | Homo sapiens | |
60 | - |
aldosterone | pH 6.0, 37°C | Homo sapiens |