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Literature summary for 1.3.1.24 extracted from

  • Miralem, T.; Lerner-Marmarosh, N.; Gibbs, P.E.; Jenkins, J.L.; Heimiller, C.; Maines, M.D.
    Interaction of human biliverdin reductase with Akt/protein kinase B and phosphatidylinositol-dependent kinase 1 regulates glycogen synthase kinase 3 activity: a novel mechanism of Akt activation (2016), FASEB J., 30, 2926-2944.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.1.24

Activating Compound

Activating Compound Comment Organism Structure
additional information the enzyme is directly activated by insulin receptor kinase Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL-21 cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
biliverdin + NADH + H+ Homo sapiens
-
 bilirubin + NAD+
-
 r
biliverdin + NADPH + H+ Homo sapiens
-
 bilirubin + NADP+
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens P53004
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
 Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA agarose column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
biliverdin + NADH + H+
-
 Homo sapiens bilirubin + NAD+
-
 r
biliverdin + NADPH + H+
-
 Homo sapiens bilirubin + NADP+
-
 r

Synonyms

Synonyms Comment Organism
biliverdin reductase A
-
 Homo sapiens
BVR
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Homo sapiens
NADPH
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme is a coactivator of Akt1 and a key mediator of the Akt1/glycogen synthase kinase 3 pathway Homo sapiens