Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.1.24 extracted from

  • Kim, S.Y.; Kang, H.T.; Choi, H.R.; Park, S.C.
    Biliverdin reductase A in the prevention of cellular senescence against oxidative stress (2011), Exp. Mol. Med., 43, 15-23.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.1.24

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
bilirubin + NADP+
-
 Homo sapiens biliverdin + NADPH + H+
-
 ?

Synonyms

Synonyms Comment Organism
biliverdin reductase A
-
 Homo sapiens
BLVRA
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
 assay at Homo sapiens

General Information

General Information Comment Organism
physiological function BLVRA may be among the most effective physiological reactive oxygen species scavenging systems and may play an important role in regulating cellular senescence Homo sapiens
physiological function H2O2 markedly induces BLVRA activity in young human diploid fibroblasts, but not in senescent human diploid fibroblasts(HDF). Depletion of BLVRA reduces the H2O2-dependent induction of heme oxygenase-1 (HO-1) in young human diploid fibroblasts, but not in senescent cells. Lentiviral RNAi transfected stable primary HDFs with reduced BLVRA expression show upregulation of the CDK inhibitor family members p16, p53, and p21, followed by cell cycle arrest in G0-G1 phase with high expression of senescence-associated beta-galactosidase Homo sapiens