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Literature summary for 1.3.1.24 extracted from
- Role of vitamin C transporters and biliverdin reductase in the dual pro-oxidant and anti-oxidant effect of biliary compounds on the placental-fetal unit in cholestasis during pregnancy (2008), Toxicol. Appl. Pharmacol., 232, 327-336.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Rattus norvegicus | 5737 | - |
| cytoplasm | - |
Homo sapiens | 5737 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| bilirubin + NADP+ | Rattus norvegicus | - |
biliverdin + NADPH + H+ | - |
r |  |
| bilirubin + NADP+ | Homo sapiens | - |
biliverdin + NADPH + H+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P53004 | - |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Hep-G2 cell | - |
Homo sapiens | - |
| JAR cell | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| placenta | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| bilirubin + NADP+ | - |
Rattus norvegicus | biliverdin + NADPH + H+ | - |
r | |
| bilirubin + NADP+ | - |
Homo sapiens | biliverdin + NADPH + H+ | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| biliverdin IXalpha reductase | - |
Rattus norvegicus |
| biliverdin IXalpha reductase | - |
Homo sapiens |
| biliverdin reductase | - |
Rattus norvegicus |
| biliverdin reductase | - |
Homo sapiens |
| BVR | - |
Rattus norvegicus |
| BVR | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Rattus norvegicus | |
| NADPH | - |
Homo sapiens | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Rattus norvegicus | in fetal liver and maternal liver and placenta ursodeoxycholic acid up-regulates biliverdin-IX reductase | up |
| Homo sapiens | in HepG2 and JAr cells taurocholic acid and ursodeoxycholic acid up-regulate biliverdin-IX reductase | up |
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Release 2023.1 (January 2023)
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