Literature summary for 1.3.1.22 extracted from

Sanchez, P.; Torres, J.M.; Vilchez, P.; Del Moral, R.G.; Ortega, E.
Effects of sulpiride on mRNA levels of steroid 5alpha-reductase isozymes in prostate of adult rats (2008), IUBMB Life, 60, 68-72.

Search for more literature for 1.3.1.22

Activating Compound

Activating Compound	Comment	Organism	Structure
sulpiride	40 mg/kg doses induce mRNA expression of 5alphaR1 and 5alpha-R2	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P24008	isozyme 5alpha-R1	-
Rattus norvegicus	P31214	isozyme 5alpha-R2	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
prostate gland	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
testosterone + NADPH + H+	-	Rattus norvegicus	5alpha-dihydrotestosterone + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
5alpha-R1	isozyme	Rattus norvegicus
5alpha-R2	isozyme	Rattus norvegicus
steroid 5alpha-reductase	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Rattus norvegicus

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Release 2023.1 (January 2023)