Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-methyl-5-(4-(2-phenylacetyl)phenyl)pyridin-2(1H)-one | 61% inhibition of type 1 steroid 5alpha reductase at 0.01 mM | Homo sapiens | |
2-(16-(acetylthio)hexadecanamido)ethyl 6-(2-(4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenoxy)acetamido)hex-4-enoate | 43% inhibition of type 1 steroid 5alpha reductase at 0.01 mM | Homo sapiens | |
2-(2-(16-(acetylthio)hexadecanamido)ethoxy)ethyl 6-(2-(4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenoxy)acetamido)hex-4-enoate | 33% inhibition of type 1 steroid 5alpha reductase at 0.01 mM | Homo sapiens | |
finasteride | - |
Homo sapiens | |
additional information | no inhibition of type 2 steroid 5alpha reductase at 0.01 mM N,N-diisopropyl-2-(4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenoxy)acetamide, N-allyl-2-(4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenoxy)acetamide, N,N-diisopropyl-2-(4-(1-methyl-6-oxopiperidin-3-yl)phenoxy)acetamide, 1-methyl-5-(4-(2-phenylacetyl)phenyl)pyridin-2(1H)-one, N,N-diisopropyl-2-(4-(2-methyl-4-oxo-3,4-dihydropyridin-1(2H)-yl)phenoxy) acetamide, 2-(16-(acetylthio)hexadecanamido)ethyl 6-(2-(4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenoxy)acetamido)hex-4-enoate, and 2-(2-(16-(acetylthio)hexadecanamido)ethoxy)ethyl 6-(2-(4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenoxy)acetamido)hex-4-enoate | Homo sapiens | |
N,N-diisopropyl-2-(4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenoxy)acetamide | 8% inhibition of type 1 steroid 5alpha reductase at 0.01 mM | Homo sapiens | |
N,N-diisopropyl-2-(4-(1-methyl-6-oxopiperidin-3-yl)phenoxy)acetamide | 6% inhibition of type 1 steroid 5alpha reductase at 0.01 mM | Homo sapiens | |
N,N-diisopropyl-2-(4-(2-methyl-4-oxo-3,4-dihydropyridin-1(2H)-yl)phenoxy)acetamide | 3% inhibition of type 1 steroid 5alpha reductase at 0.01 mM | Homo sapiens | |
N-allyl-2-(4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenoxy)acetamide | 6% inhibition of type 1 steroid 5alpha reductase at 0.01 mM | Homo sapiens | |
N-allyl-2-(4-(2-methyl-4-oxo-3,4-dihydropyridin-1(2H)-yl)phenoxy)acetamide | 8% inhibition of type 1 steroid 5alpha reductase at 0.01 mM and 12% inhibition of type 2 steroid 5alpha reductase at 0.01 mM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
testosterone + NADPH + H+ | - |
Homo sapiens | 5alpha-dihydrotestosterone + NADP+ + H+ | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
steroid 5alpha-reductase | - |
Homo sapiens |
type 1 SR | - |
Homo sapiens |
type 1 steroid 5alpha reductase | - |
Homo sapiens |
type 2 SR | - |
Homo sapiens |
type 2 steroid 5alpha reductase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | dependent | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000025 | - |
type 2 steroid 5alpha reductase inhibition | Homo sapiens | finasteride | |
0.000453 | - |
type 1 steroid 5alpha reductase inhibition | Homo sapiens | finasteride |