Literature summary for 1.3.1.22 extracted from

Killian, J.; Pratis, K.; Clifton, R.J.; Stanton, P.G.; Robertson, D.M.; O'Donnell, L.
5alpha-reductase isoenzymes 1 and 2 in the rat testis during postnatal development (2003), Biol. Reprod., 68, 1711-1718.

Search for more literature for 1.3.1.22

Inhibitors

Inhibitors	Comment	Organism	Structure
21,21-pentamethylene-4-aza-5alpha-pregn-1-ene-3,20-dione	i.e. L685,273, suppresses testicular enzyme activity during puberty by 75-86%	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Rattus norvegicus	role of enzyme in initiation of spermatogenensis	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	isoforms I and II	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
testis	postnatal animals, enzyme activity is low in 10-day old testis, peaks between days 20 and 40 during puberty and then declines	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	role of enzyme in initiation of spermatogenensis	Rattus norvegicus	?	-	?

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Release 2023.1 (January 2023)