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Literature summary for 1.3.1.22 extracted from
- Cloning, expression and functional characterization of type 1 and type 2 steroid 5alpha-reductase from cynomolgus monkey: comparison with human and rat isoenzymes (1995), J. Steroid Biochem. Mol. Biol., 52, 307-319.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| monkey SR type 1 cDNA expression in CHO-cells | Macaca fascicularis |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-methyl-4-azasteroids | competitive | Homo sapiens | |
| 4-methyl-4-azasteroids | competitive | Macaca fascicularis | |
| 4-methyl-4-azasteroids | competitive | Rattus norvegicus | |
| 4-methyl-azasteroid | - |
Homo sapiens |  |
| 4-methyl-azasteroid | - |
Macaca fascicularis | |
| 4-methyl-azasteroid | - |
Rattus norvegicus | |
| acrylate episteride | - |
Homo sapiens | |
| acrylate episteride | - |
Macaca fascicularis | |
| acrylate episteride | - |
Rattus norvegicus | |
| finasteride | - |
Homo sapiens | |
| finasteride | - |
Macaca fascicularis | |
| finasteride | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0002 | - |
testosterone | isoenzyme 2 | Macaca fascicularis | |
| 0.0002 | - |
progesterone | isoenzyme 2 | Macaca fascicularis | |
| 0.0002 | - |
20alpha-hydroxyprogesterone | isoenzyme 1 | Homo sapiens | |
| 0.0003 | - |
progesterone | isoenzyme 2 | Homo sapiens | |
| 0.0003 | - |
progesterone | isoenzyme 1 | Homo sapiens | |
| 0.0003 | - |
progesterone | isoenzyme 1 | Macaca fascicularis | |
| 0.0004 | - |
androstenedione | isoenzyme 2 | Macaca fascicularis | |
| 0.0004 | - |
20alpha-hydroxyprogesterone | isoenzyme 2 | Homo sapiens | |
| 0.0005 | - |
20alpha-hydroxyprogesterone | isoenzyme 1 | Macaca fascicularis | |
| 0.0006 | - |
androstenedione | isoenzyme 1 | Macaca fascicularis | |
| 0.0007 | - |
testosterone | isoenzyme 2 | Homo sapiens | |
| 0.0008 | - |
androstenedione | isoenzyme 2 | Homo sapiens | |
| 0.001 | - |
androstenedione | isoenzyme 1 | Homo sapiens | |
| 0.002 | - |
corticosterone | isoenzyme 2 | Macaca fascicularis | |
| 0.002 | - |
testosterone | isoenzyme 1 | Macaca fascicularis | |
| 0.0035 | - |
testosterone | isoenzyme 1 | Homo sapiens | |
| 0.004 | - |
corticosterone | isoenzyme 2 | Homo sapiens | |
| 0.008 | - |
corticosterone | isoenzyme 1 | Macaca fascicularis | |
| 0.018 | - |
corticosterone | isoenzyme 1 | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Macaca fascicularis | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| prostate gland | - |
Homo sapiens | - |
| prostate gland | - |
Rattus norvegicus | - |
| prostate gland | - |
Macaca fascicularis | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 20-alpha-hydroxypregn-4-ene-3one + NADPH | - |
Homo sapiens | 20-alpha-hydroxy-5alpha-pregnan-3-one + NADP+ | - |
? | |
| 20-alpha-hydroxypregn-4-ene-3one + NADPH | - |
Macaca fascicularis | 20-alpha-hydroxy-5alpha-pregnan-3-one + NADP+ | - |
? | |
| androstenedione + NADPH + H+ | - |
Homo sapiens | 5alpha-androstan-3,17-dione + NADP+ | - |
? | |
| androstenedione + NADPH + H+ | - |
Rattus norvegicus | 5alpha-androstan-3,17-dione + NADP+ | - |
? | |
| androstenedione + NADPH + H+ | - |
Macaca fascicularis | 5alpha-androstan-3,17-dione + NADP+ | - |
? | |
| corticosterone + NADPH + H+ | - |
Homo sapiens | 5alpha-dihydrocorticosterone + NADP+ | - |
r | |
| corticosterone + NADPH + H+ | - |
Macaca fascicularis | 5alpha-dihydrocorticosterone + NADP+ | - |
r | |
| deoxycorticosterone + NADPH | - |
Homo sapiens | 21-hydroxy-5alpha-pregnan-3,20-dione | - |
? | |
| deoxycorticosterone + NADPH | - |
Rattus norvegicus | 21-hydroxy-5alpha-pregnan-3,20-dione | - |
? | |
| deoxycorticosterone + NADPH | - |
Macaca fascicularis | 21-hydroxy-5alpha-pregnan-3,20-dione | - |
? | |
| progesterone + NADPH + H+ | - |
Homo sapiens | 5alpha-pregnan-3,20-dione + NADP+ | - |
? | |
| progesterone + NADPH + H+ | - |
Rattus norvegicus | 5alpha-pregnan-3,20-dione + NADP+ | - |
? | |
| progesterone + NADPH + H+ | - |
Macaca fascicularis | 5alpha-pregnan-3,20-dione + NADP+ | - |
? | |
| testosterone + NADPH + H+ | - |
Homo sapiens | 17beta-hydroxy-5alpha-androstan-3-one + NADP+ | - |
? | |
| testosterone + NADPH + H+ | - |
Rattus norvegicus | 17beta-hydroxy-5alpha-androstan-3-one + NADP+ | - |
? | |
| testosterone + NADPH + H+ | - |
Macaca fascicularis | 17beta-hydroxy-5alpha-androstan-3-one + NADP+ | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5 | - |
recombinant monkey 5alpha-reductase isozyme 2 | Macaca fascicularis |
| 5 | - |
recombinant human 5alpha-reductase isozyme 2 | Homo sapiens |
| 7.5 | - |
recombinant human 5alpha-reductase isozyme 1 | Homo sapiens |
| 8 | - |
recombinant monkey 5alpha-reductase isozyme 1 | Macaca fascicularis |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4.5 | 9.5 | recombinant human 5alpha-reductase isozyme 2 | Homo sapiens |
| 4.5 | 7.5 | recombinant monkey 5alpha-reductase isozyme 2 | Macaca fascicularis |
| 4.5 | 9 | recombinant human 5alpha-reductase isozyme 1 | Homo sapiens |
| 5.5 | 9 | recombinant monkey 5alpha-reductase isozyme 1 | Macaca fascicularis |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000003 | - |
acylate episteride | iosenzyme 2 | Homo sapiens | |
| 0.0000005 | - |
acylate episteride | iosenzyme 2 | Macaca fascicularis | |
| 0.000001 | - |
finasteride | iosenzyme 2 | Homo sapiens | |
| 0.000002 | - |
4-methyl-azasteroid | iosenzyme 2 | Macaca fascicularis | |
| 0.000003 | - |
4-methyl-azasteroid | iosenzyme 1 | Homo sapiens | |
| 0.000003 | - |
4-methyl-azasteroid | iosenzyme 1 | Macaca fascicularis | |
| 0.000003 | - |
4-methyl-azasteroid | iosenzyme 2 | Rattus norvegicus | |
| 0.000004 | - |
finasteride | iosenzyme 2 | Rattus norvegicus | |
| 0.000004 | - |
4-methyl-azasteroid | iosenzyme 2 | Homo sapiens | |
| 0.000004 | - |
acylate episteride | iosenzyme 2 | Rattus norvegicus | |
| 0.000005 | - |
finasteride | iosenzyme 2 | Macaca fascicularis | |
| 0.000006 | - |
finasteride | iosenzyme 1 | Rattus norvegicus | |
| 0.000008 | - |
4-methyl-azasteroid | iosenzyme 1 | Rattus norvegicus | |
| 0.00002 | - |
acylate episteride | iosenzyme 1 | Rattus norvegicus | |
| 0.00022 | - |
finasteride | iosenzyme 1 | Macaca fascicularis | |
| 0.0005 | - |
acylate episteride | iosenzyme 1 | Macaca fascicularis | |
| 0.001 | - |
finasteride | iosenzyme 1 | Homo sapiens | |
| 0.0041 | - |
acylate episteride | iosenzyme 1 | Homo sapiens |
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