Literature summary for 1.3.1.22 extracted from

Bhattacharyya, A.K.; Chavan, A.J.; Haley, B.E.; Taylor, M.F.; Collins, D.C.
Identification of the NADP(H) binding site of rat liver microsomal 5alpha-reductase (isoenzyme-1): purification of a photolabeled peptide corresponding to the adenine binding domain (1995), Biochemistry, 34, 3663-3669.

Search for more literature for 1.3.1.22

Inhibitors

Inhibitors	Comment	Organism	Structure
3-Androstene-3-carboxylic acids	uncompetitive	Rattus norvegicus
4-methyl-4-azasteroids	competitive	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Rattus norvegicus	-	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
26000	-	10% SDS-PAGE	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
three-step purification of a photolabeled tryptic peptide corresponding to the NADP(H) binding domain of 5alpha-reductase	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	absolute requirement for NADPH	Rattus norvegicus
NADPH	the NADPH following amino acids of 5alpha-reductase are identified as NADPH-binding site: NLRKPGETGYK	Rattus norvegicus

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Release 2023.1 (January 2023)