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Literature summary for 1.3.1.22 extracted from
- Subcellular distribution and properties of progesterone (delta4-steroid) 5alpha-reductase in rat medial basal hypothalamus (1975), J. Biol. Chem., 250, 7997-8003.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 17beta-estradiol | noncompetitive inhibition | Rattus norvegicus |  |
| 20alpha-hydroxypregn-4-en-3-one | competitive | Rattus norvegicus | |
| testosterone | poor competitive inhibitor | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Rattus norvegicus | |
| 0.00048 | - |
progesterone | - |
Rattus norvegicus | |
| 0.00086 | - |
20alpha-hydroxypregn-4-en-3-one | - |
Rattus norvegicus | |
| 0.016 | - |
testosterone | - |
Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
female rat | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| hypothalamus | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 20alpha-hydroxy-4-pregnen-3-one + NADPH | more reactive than progesterone | Rattus norvegicus | 20alpha-hydroxy-5-beta-pregnan-3-one + NADP+ | - |
? | |
| additional information | testosterone is less effective | Rattus norvegicus | ? | - |
? | |
| progesterone + NADPH + H+ | - |
Rattus norvegicus | 5alpha-pregnan-3-20-dione + NADP+ | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 32 | - |
- |
Rattus norvegicus |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 15 | 42 | 15°C: about 50% of activity maximum, 42°C: about 30% of activity maximum | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 7.2 | - |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 8 | pH 5.0: about 20% of activity maximum, pH 8.0: about 20% of activity maximum | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | cannot be replaced by NADH | Rattus norvegicus | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00006 | - |
20alpha-hydroxypregn-4-en-3-one | - |
Rattus norvegicus | |
| 0.026 | - |
17beta-estradiol | intercept inhibition constant | Rattus norvegicus | |
| 0.036 | - |
17beta-estradiol | slope inhibition constant | Rattus norvegicus | |
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Release 2023.1 (January 2023)
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