Inhibitors | Comment | Organism | Structure |
---|---|---|---|
17beta-estradiol | noncompetitive inhibition | Rattus norvegicus | |
20alpha-hydroxypregn-4-en-3-one | competitive | Rattus norvegicus | |
testosterone | poor competitive inhibitor | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Rattus norvegicus | |
0.00048 | - |
progesterone | - |
Rattus norvegicus | |
0.00086 | - |
20alpha-hydroxypregn-4-en-3-one | - |
Rattus norvegicus | |
0.016 | - |
testosterone | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
female rat | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hypothalamus | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
20alpha-hydroxy-4-pregnen-3-one + NADPH | more reactive than progesterone | Rattus norvegicus | 20alpha-hydroxy-5-beta-pregnan-3-one + NADP+ | - |
? | |
additional information | testosterone is less effective | Rattus norvegicus | ? | - |
? | |
progesterone + NADPH + H+ | - |
Rattus norvegicus | 5alpha-pregnan-3-20-dione + NADP+ | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
32 | - |
- |
Rattus norvegicus |
Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|
15 | 42 | 15°C: about 50% of activity maximum, 42°C: about 30% of activity maximum | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | 7.2 | - |
Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5 | 8 | pH 5.0: about 20% of activity maximum, pH 8.0: about 20% of activity maximum | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | cannot be replaced by NADH | Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00006 | - |
20alpha-hydroxypregn-4-en-3-one | - |
Rattus norvegicus | |
0.026 | - |
17beta-estradiol | intercept inhibition constant | Rattus norvegicus | |
0.036 | - |
17beta-estradiol | slope inhibition constant | Rattus norvegicus |