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Literature summary for 1.3.1.21 extracted from

  • Kim, H.Y.; Korade, Z.; Tallman, K.A.; Liu, W.; Weaver, C.D.; Mirnics, K.; Porter, N.A.
    Inhibitors of 7-dehydrocholesterol reductase: screening of a collection of pharmacologically active compounds in Neuro2a cells (2016), Chem. Res. Toxicol., 29, 892-900.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.1.21

Inhibitors

Inhibitors Comment Organism Structure
1-[3-(2,4,6-trimethoxybenzoyl)propyl]-pyrrolidinium chloride
-
 Mus musculus
acebutolol
-
 Mus musculus
altanserin
-
 Mus musculus
aripiprazole
-
 Mus musculus
AY9944 i.e.trans-1,4-bis(2-chloro-benzylaminomethyl) Mus musculus
buspirone
-
 Mus musculus
captopril
-
 Mus musculus
CGS 12066B
-
 Mus musculus
cisapride
-
 Mus musculus
clobenpropit
-
 Mus musculus
dofetilide
-
 Mus musculus
donepezil
-
 Mus musculus
droperidol
-
 Mus musculus
E-4031
-
 Mus musculus
esmolol
-
 Mus musculus
fluoxetine
-
 Mus musculus
formoterol
-
 Mus musculus
haloperidol
-
 Mus musculus
ifenprodil
-
 Mus musculus
isoxsuprine
-
 Mus musculus
lobeline
-
 Mus musculus
lofexidine
-
 Mus musculus
loxoprofen
-
 Mus musculus
N-(3-trifluoromethylphenyl)piperazine
-
 Mus musculus
nafadotride
-
 Mus musculus
naftopidil
-
 Mus musculus
nefazodone
-
 Mus musculus
oxybutynin
-
 Mus musculus
pergolide
-
 Mus musculus
perospirone
-
 Mus musculus
pirenperone
-
 Mus musculus
procaine
-
 Mus musculus
risperidone
-
 Mus musculus
salmeterol
-
 Mus musculus
trazodone
-
 Mus musculus
vesamicol
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + NADP+ Mus musculus
-
 cholesta-5,7-dien-3beta-ol + NADPH + H+
-
 ?
desmosterol + NADP+ Mus musculus
-
 7-dehydrodesmosterol + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Neuro2A cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + NADP+
-
 Mus musculus cholesta-5,7-dien-3beta-ol + NADPH + H+
-
 ?
desmosterol + NADP+
-
 Mus musculus 7-dehydrodesmosterol + NADPH + H+
-
 ?

Synonyms

Synonyms Comment Organism
Dhcr7
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Mus musculus