Literature summary for 1.3.1.21 extracted from

Horling, A.; Mueller, C.; Barthel, R.; Bracher, F.; Imming, P.
A new class of selective and potent 7-dehydrocholesterol reductase inhibitors (2012), J. Med. Chem., 55, 7614-7622.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-[2-(4-chlorophenyl)ethyl]-6-hydroxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline	strong and selective inhibition of 7-dehydrocholesterol reductase, stronger inhibition of overall cholesterol biosynthesis than BM 15.766, presently the most selective known inhibitor of 7-DHCR	Homo sapiens
BM 15.766	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HL-60 cell	-	Homo sapiens	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0000023	-	whole-cell assay, pH not specified in the publication, temperature not specified in the publication	Homo sapiens	BM 15.766
0.0005	-	whole-cell assay, pH not specified in the publication, temperature not specified in the publication	Homo sapiens	2-[2-(4-chlorophenyl)ethyl]-6-hydroxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline

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Release 2023.1 (January 2023)