Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.1.21 extracted from

  • Honda, A.; Salen, G.; Shefer, S.; Batta, A.K.; Honda, M.; Xu, G.; Tint, G.S.; Matsuzaki, Y.; Shoda, J.; Tanaka, N.
    Bile acid synthesis in the Smith-Lemli-Opitz syndrome: effects of dehydrocholesterols on cholesterol 7.alpha-hydroxylase and 27-hydroxylase activities in rat liver (1999), J. Lipid Res., 40, 1520-1528.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-(2-[1-(n-chlorocinnamyl) piperazin-4-yl] ethyl) benzoic acid
-
Homo sapiens
4-(2-[1-(n-chlorocinnamyl) piperazin-4-yl] ethyl) benzoic acid i.e. BM 15.766 non-competitive Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesta-5,7-dien-3-beta-ol + NADPH Rattus norvegicus
-
cholesterol + NADP+
-
?
cholesta-5,7-dien-3-beta-ol + NADPH Homo sapiens defect in cholesterol biosynthesis cause multiple congenital, developmental and morphogenic anomalies, e.g. the Smith-Lemli-Opitz syndrome due to a gene mutation, overview cholesterol + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesta-5,7-dien-3-beta-ol + NADPH
-
Rattus norvegicus cholesterol + NADP+
-
?
cholesta-5,7-dien-3-beta-ol + NADPH defect in cholesterol biosynthesis cause multiple congenital, developmental and morphogenic anomalies, e.g. the Smith-Lemli-Opitz syndrome due to a gene mutation, overview Homo sapiens cholesterol + NADP+
-
?
cholesta-5,7-dien-3beta-ol + NADPH
-
Homo sapiens cholesterol + NADP+
-
?
cholesta-5,7-dien-3beta-ol + NADPH
-
Rattus norvegicus cholesterol + NADP+
-
?
ergosta-5,7,22-trien-3beta-ol + NADPH i.e. ergosterol Rattus norvegicus ergosta-5,22-diene-3beta-ol + NADP+
-
?
ergosta-5,7,22-trien-3beta-ol + NADPH i.e. ergosterol Homo sapiens ergosta-5,22-diene-3beta-ol + NADP+ i.e. brassicasterol ?

Synonyms

Synonyms Comment Organism
3-hydroxysterol DELTA7-reductase
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens
NADPH
-
Rattus norvegicus