Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-(2-[1-(n-chlorocinnamyl) piperazin-4-yl] ethyl) benzoic acid | i.e. BM 15.766 non-competitive | Rattus norvegicus | |
brassicasterol | higher concentration, competitive | Rattus norvegicus | |
epicholesterol | higher concentration, competitive | Rattus norvegicus | |
sitosterol | higher concentration, competitive | Rattus norvegicus | |
trans-1,4-Bis-(2-chlorobenzylaminomethyl)cyclohexane dihydrochloride | i.e. AY-9944, hypercholesterolaemic drug; non-competitive | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
smooth endoplasmic reticulum | microsomal | Rattus norvegicus | 5790 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesta-5,7-dien-3-beta-ol + NADPH | Rattus norvegicus | - |
cholesterol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
cholesterol + NADP+ = cholesta-5,7-dien-3beta-ol + NADPH + H+ | mechanism | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.000756 | - |
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7-dehydrositosterol + NADPH | 25% of that with 7-dehydrocholesterol | Rattus norvegicus | sitosterol + NADP+ | - |
? | |
cholesta-5,7-dien-3-beta-ol + NADPH | - |
Rattus norvegicus | cholesterol + NADP+ | - |
? | |
cholesta-5,7-dien-3beta-ol + NADPH | - |
Rattus norvegicus | cholesterol + NADP+ | - |
? | |
cholesta-7-en-3beta-ol + NADPH | not: | Rattus norvegicus | ? | - |
? | |
ergosta-5,7,22-trien-3beta-ol + NADPH | 25% activity of that with 7-dehydrocholesterol | Rattus norvegicus | ergosta-5,22-diene-3beta-ol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3-hydroxysterol DELTA7-reductase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Rattus norvegicus |