Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.1.21 extracted from

  • Shefer, S.; Salen, G.; Honda, A.; Batta, A.K.; Nguyen, L.B.; Tint, G.S.; Ioannou, Y.A.; Desnick, R.
    Regulation of rat hepatic 3beta-hydroxysterol DELTA7-reductase: substrate specificity, competitive and non-competitive inhibition, and phosphorylation/dephosphorylation (1998), J. Lipid Res., 39, 2471-2476.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-(2-[1-(n-chlorocinnamyl) piperazin-4-yl] ethyl) benzoic acid i.e. BM 15.766 non-competitive Rattus norvegicus
brassicasterol higher concentration, competitive Rattus norvegicus
epicholesterol higher concentration, competitive Rattus norvegicus
sitosterol higher concentration, competitive Rattus norvegicus
trans-1,4-Bis-(2-chlorobenzylaminomethyl)cyclohexane dihydrochloride i.e. AY-9944, hypercholesterolaemic drug; non-competitive Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
smooth endoplasmic reticulum microsomal Rattus norvegicus 5790
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesta-5,7-dien-3-beta-ol + NADPH Rattus norvegicus
-
cholesterol + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
cholesterol + NADP+ = cholesta-5,7-dien-3beta-ol + NADPH + H+ mechanism Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.000756
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7-dehydrositosterol + NADPH 25% of that with 7-dehydrocholesterol Rattus norvegicus sitosterol + NADP+
-
?
cholesta-5,7-dien-3-beta-ol + NADPH
-
Rattus norvegicus cholesterol + NADP+
-
?
cholesta-5,7-dien-3beta-ol + NADPH
-
Rattus norvegicus cholesterol + NADP+
-
?
cholesta-7-en-3beta-ol + NADPH not: Rattus norvegicus ?
-
?
ergosta-5,7,22-trien-3beta-ol + NADPH 25% activity of that with 7-dehydrocholesterol Rattus norvegicus ergosta-5,22-diene-3beta-ol + NADP+
-
?

Synonyms

Synonyms Comment Organism
3-hydroxysterol DELTA7-reductase
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Rattus norvegicus