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Literature summary for 1.3.1.20 extracted from

  • Wang, H.W.; Lin, C.P.; Chiu, J.H.; Chow, K.C.; Kuo, K.T.; Lin, C.S.; Wang, L.S.
    Reversal of inflammation-associated dihydrodiol dehydrogenases (AKR1C1 and AKR1C2) overexpression and drug resistance in nonsmall cell lung cancer cells by wogonin and chrysin (2007), Int. J. Cancer, 120, 2019-2027.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
interleukin-6 stimulates enzyme expression Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
chrysin inhibits enzyme expression at concentrations higher than 0.01 mM; inhibits enzyme expression at concentrations higher than 0.01 mM Homo sapiens
additional information enzyme expression is not inhibited by baicalin and baicalein; enzyme expression is not inhibited by baicalin and baicalein Homo sapiens
wogonin inhibits enzyme expression at concentrations higher than 0.0025 mM; inhibits enzyme expression at concentrations higher than 0.0025 mM Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34000
-
SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P52895 aldo-keto reductase family 1 member C2, AKR1C2
-
Homo sapiens Q04828 aldo-keto reductase family 1 member C1, AKR1C1
-

Source Tissue

Source Tissue Comment Organism Textmining
non-small cell lung cancer cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
Homo sapiens catechol + NAD(P)H
-
?

Synonyms

Synonyms Comment Organism
AKR1C1
-
Homo sapiens
AKR1C2
-
Homo sapiens
DDH member of the aldo-keto reductases superfamily which plays a central role in the metabolism of steroid hormones, prostaglandins and xenobiotics Homo sapiens
dihydrodiol dehydrogenase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD(P)+
-
Homo sapiens