BRENDA - Enzyme Database show
show all sequences of 1.3.1.20

Structural and functional features of dimeric dihydrodiol dehydrogenase

Carbone, V.; Hara, A.; El-Kabbani, O.; Cell. Mol. Life Sci. 65, 1464-1474 (2008)

Data extracted from this reference:

Crystallization (Commentary)
Crystallization
Organism
-
Macaca fascicularis
Engineering
Amino acid exchange
Commentary
Organism
F279A
the mutation affects inhibition and substrate affinity
Macaca fascicularis
K97M
mutant shows almost complete abrogation in activity for D-xylose oxidation and NADP+, and very poor activity with camphorquinone reduction and NADPH
Macaca fascicularis
K97R
mutant shows almost complete abrogation in activity for D-xylose oxidation and NADP+, and very poor activity with camphorquinone reduction and NADPH
Macaca fascicularis
W125A
the mutation affects inhibition and substrate affinity
Macaca fascicularis
W254A
the mutation affects inhibition and substrate affinity
Macaca fascicularis
Inhibitors
Inhibitors
Commentary
Organism
Structure
2,6-dihydroxyanthraquinone
competitive inhibitor
Macaca fascicularis
2,6-dihydroxyanthraquinone
competitive inhibitor
Sus scrofa
4-hydroxyacetophenone
competitive inhibitor
Macaca fascicularis
4-hydroxyacetophenone
competitive inhibitor
Sus scrofa
isoascorbic acid
competitive inhibitor
Macaca fascicularis
isoascorbic acid
competitive inhibitor
Sus scrofa
L-ascorbic acid
competitive inhibitor
Macaca fascicularis
L-ascorbic acid
competitive inhibitor
Sus scrofa
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
activates
Macaca fascicularis
Mg2+
activates
Sus scrofa
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bos taurus
Q148L6
-
-
Macaca fascicularis
-
-
-
Mus musculus
Q9DBB8
-
-
Pongo abelii
Q5R5J5
-
-
Sus scrofa
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
kidney
-
Macaca fascicularis
-
lens
-
Mus musculus
-
additional information
not found in liver and kidney
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
camphorquinone + NAD(P)H
-
686023
Sus scrofa
(1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+
-
-
-
?
camphorquinone + NAD(P)H
-
686023
Macaca fascicularis
(1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+
-
-
-
?
camphorquinone + NAD(P)H
-
686023
Mus musculus
(1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+
-
-
-
?
camphorquinone + NAD(P)H
-
686023
Pongo abelii
(1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+
-
-
-
?
camphorquinone + NAD(P)H
-
686023
Bos taurus
(1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+
-
-
-
?
D-xylose + NADP+
-
686023
Sus scrofa
D-xylono-1,5-lactone + NADPH + H+
-
-
-
?
D-xylose + NADP+
-
686023
Macaca fascicularis
D-xylono-1,5-lactone + NADPH + H+
-
-
-
?
D-xylose + NADP+
-
686023
Mus musculus
D-xylono-1,5-lactone + NADPH + H+
-
-
-
?
D-xylose + NADP+
-
686023
Pongo abelii
D-xylono-1,5-lactone + NADPH + H+
-
-
-
?
D-xylose + NADP+
-
686023
Bos taurus
D-xylono-1,5-lactone + NADPH + H+
-
-
-
?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
686023
Sus scrofa
catechol + NAD(P)H
the reaction produces a ketol which then enolizes to the catechol
-
-
?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
686023
Macaca fascicularis
catechol + NAD(P)H
the reaction produces a ketol which then enolizes to the catechol
-
-
?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
686023
Mus musculus
catechol + NAD(P)H
the reaction produces a ketol which then enolizes to the catechol
-
-
?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
686023
Pongo abelii
catechol + NAD(P)H
the reaction produces a ketol which then enolizes to the catechol
-
-
?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
686023
Bos taurus
catechol + NAD(P)H
the reaction produces a ketol which then enolizes to the catechol
-
-
?
Subunits
Subunits
Commentary
Organism
dimer
x-ray crystallography
Macaca fascicularis
dimer
x-ray crystallography
Sus scrofa
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
-
Bos taurus
NAD+
-
Macaca fascicularis
NAD+
-
Mus musculus
NAD+
-
Pongo abelii
NAD+
-
Sus scrofa
NADP+
dependent on
Bos taurus
NADP+
dependent on
Mus musculus
NADP+
dependent on
Pongo abelii
NADP+
dependent on
Sus scrofa
NADP+
dependent on
Macaca fascicularis
IC50 Value
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.043
-
-
Sus scrofa
isoascorbic acid
0.45
-
-
Sus scrofa
L-ascorbic acid
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
-
Bos taurus
NAD+
-
Macaca fascicularis
NAD+
-
Mus musculus
NAD+
-
Pongo abelii
NAD+
-
Sus scrofa
NADP+
dependent on
Bos taurus
NADP+
dependent on
Mus musculus
NADP+
dependent on
Pongo abelii
NADP+
dependent on
Sus scrofa
NADP+
dependent on
Macaca fascicularis
Crystallization (Commentary) (protein specific)
Crystallization
Organism
-
Macaca fascicularis
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
F279A
the mutation affects inhibition and substrate affinity
Macaca fascicularis
K97M
mutant shows almost complete abrogation in activity for D-xylose oxidation and NADP+, and very poor activity with camphorquinone reduction and NADPH
Macaca fascicularis
K97R
mutant shows almost complete abrogation in activity for D-xylose oxidation and NADP+, and very poor activity with camphorquinone reduction and NADPH
Macaca fascicularis
W125A
the mutation affects inhibition and substrate affinity
Macaca fascicularis
W254A
the mutation affects inhibition and substrate affinity
Macaca fascicularis
IC50 Value (protein specific)
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.043
-
-
Sus scrofa
isoascorbic acid
0.45
-
-
Sus scrofa
L-ascorbic acid
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
2,6-dihydroxyanthraquinone
competitive inhibitor
Macaca fascicularis
2,6-dihydroxyanthraquinone
competitive inhibitor
Sus scrofa
4-hydroxyacetophenone
competitive inhibitor
Macaca fascicularis
4-hydroxyacetophenone
competitive inhibitor
Sus scrofa
isoascorbic acid
competitive inhibitor
Macaca fascicularis
isoascorbic acid
competitive inhibitor
Sus scrofa
L-ascorbic acid
competitive inhibitor
Macaca fascicularis
L-ascorbic acid
competitive inhibitor
Sus scrofa
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
activates
Macaca fascicularis
Mg2+
activates
Sus scrofa
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
kidney
-
Macaca fascicularis
-
lens
-
Mus musculus
-
additional information
not found in liver and kidney
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
camphorquinone + NAD(P)H
-
686023
Sus scrofa
(1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+
-
-
-
?
camphorquinone + NAD(P)H
-
686023
Macaca fascicularis
(1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+
-
-
-
?
camphorquinone + NAD(P)H
-
686023
Mus musculus
(1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+
-
-
-
?
camphorquinone + NAD(P)H
-
686023
Pongo abelii
(1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+
-
-
-
?
camphorquinone + NAD(P)H
-
686023
Bos taurus
(1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+
-
-
-
?
D-xylose + NADP+
-
686023
Sus scrofa
D-xylono-1,5-lactone + NADPH + H+
-
-
-
?
D-xylose + NADP+
-
686023
Macaca fascicularis
D-xylono-1,5-lactone + NADPH + H+
-
-
-
?
D-xylose + NADP+
-
686023
Mus musculus
D-xylono-1,5-lactone + NADPH + H+
-
-
-
?
D-xylose + NADP+
-
686023
Pongo abelii
D-xylono-1,5-lactone + NADPH + H+
-
-
-
?
D-xylose + NADP+
-
686023
Bos taurus
D-xylono-1,5-lactone + NADPH + H+
-
-
-
?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
686023
Sus scrofa
catechol + NAD(P)H
the reaction produces a ketol which then enolizes to the catechol
-
-
?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
686023
Macaca fascicularis
catechol + NAD(P)H
the reaction produces a ketol which then enolizes to the catechol
-
-
?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
686023
Mus musculus
catechol + NAD(P)H
the reaction produces a ketol which then enolizes to the catechol
-
-
?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
686023
Pongo abelii
catechol + NAD(P)H
the reaction produces a ketol which then enolizes to the catechol
-
-
?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
686023
Bos taurus
catechol + NAD(P)H
the reaction produces a ketol which then enolizes to the catechol
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
dimer
x-ray crystallography
Macaca fascicularis
dimer
x-ray crystallography
Sus scrofa
Other publictions for EC 1.3.1.20
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
740358
Liu
Metabolites analysis, metaboli ...
Ruditapes philippinarum
Ecotoxicol. Environ. Saf.
107
251-259
2014
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697571
Chang
Overexpression of dihydrodiol ...
Homo sapiens
Digest. Dis. Sci.
54
342-347
2009
-
1
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
2
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684150
Carbone
Structure of monkey dimeric di ...
Macaca fascicularis, Macaca fuscata
Acta Crystallogr. Sect. D
64
532-542
2008
-
-
2
2
30
-
4
26
-
-
-
2
-
2
-
-
2
-
-
-
-
-
4
2
-
-
-
10
-
-
-
3
-
-
23
-
-
2
3
2
30
-
23
4
-
26
-
-
-
2
-
-
-
2
-
-
-
-
4
2
-
-
-
10
-
-
-
-
-
-
-
-
-
-
686023
Carbone
Structural and functional feat ...
Bos taurus, Macaca fascicularis, Mus musculus, Pongo abelii, Sus scrofa
Cell. Mol. Life Sci.
65
1464-1474
2008
-
-
-
1
5
-
8
-
-
2
-
-
-
5
-
-
-
-
-
3
-
-
15
2
-
-
-
-
-
-
-
10
-
-
2
-
-
-
10
1
5
-
2
8
-
-
-
2
-
-
-
-
-
-
-
3
-
-
15
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
701119
Carbone
Structures of dimeric dihydrod ...
Macaca fascicularis
Proteins Struct. Funct. Genet.
70
176-187
2008
-
-
1
1
3
-
1
-
-
-
1
1
-
1
-
-
1
-
-
-
3
-
1
2
-
-
1
-
1
-
-
2
-
-
1
-
-
1
2
1
3
-
1
1
-
-
-
-
1
1
-
-
-
1
-
-
3
-
1
2
-
-
1
-
1
-
-
-
-
-
-
-
-
-
685913
Pan
Dihydrodiol dehydrogenase in d ...
Homo sapiens
Cancer Chemother. Pharmacol.
59
697-702
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687141
Wang
Reversal of inflammation-assoc ...
Homo sapiens
Int. J. Cancer
120
2019-2027
2007
1
-
-
-
-
-
3
-
-
-
1
-
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
2
-
-
2
-
-
-
-
6
-
-
-
-
2
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689972
Carbone
-
Structures of dimeric dihydrod ...
Macaca fascicularis
Proteins Struct. Funct. Bioinform.
70
176-187
2007
-
-
1
1
3
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
1
-
-
1
-
-
-
-
1
-
-
1
-
-
1
1
1
3
-
1
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
671358
Hung
Expression of dihydrodiol dehy ...
Homo sapiens
Anticancer Res.
26
2949-2956
2006
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673371
Cheng
A possible role for dihydrodio ...
Homo sapiens
Environ. Mol. Mutagen.
48
14-21
2006
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675089
Chow
Expression of dihydrodiol dehy ...
Homo sapiens
J. Dermatol. Sci.
41
205-212
2006
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673903
Chen
Overexpression of dihydrodiol ...
Homo sapiens
Gynecol. Oncol.
97
110-117
2005
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
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-
-
-
-
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-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
655159
Deng
Ubiquitous induction of resist ...
Homo sapiens
Cancer Chemother. Pharmacol.
54
301-307
2004
-
-
-
-
-
-
7
-
-
-
-
-
-
1
-
-
-
-
-
1
5
-
1
-
-
-
-
-
-
-
-
1
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2004
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655744
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Inverse expression of dihydrod ...
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Int. J. Cancer
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Tang
Hydroxychavicol modulates benz ...
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656885
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Reduction of dihydrodiol dehyd ...
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349258
El-Kabbani
Crystallization and preliminar ...
Macaca fuscata
Acta Crystallogr. Sect. D
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1
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655321
Higaki
Molecular characterization of ...
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2002
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Deng
Increased expression of dihydr ...
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286128
Aoki
Identity of dimeric dihydrodio ...
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349250
Terada
Site-directed mutagenesis stud ...
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Asada
Roles of His-79 and Tyr-180 of ...
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349252
Kume
Characterization of a novel va ...
Homo sapiens
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Burczynski
Expression and characterizatio ...
Homo sapiens
Biochemistry
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Matsuura
Roles of the C-terminal domain ...
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349262
Matsuura
Identification of amino acid r ...
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349263
Bennett
Steroid recognition and regula ...
Rattus norvegicus
Structure
5
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1997
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349259
Hara
Relationship of human liver di ...
Homo sapiens
Biochem. J.
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Miyabe
Kinetic studies of the inhibit ...
Homo sapiens
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Deyashiki
Expression and kinetic propert ...
Homo sapiens
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349256
Nanjo
Enzymic characterization of a ...
Bos taurus
Biochim. Biophys. Acta
1244
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1995
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Purification and characterizat ...
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Hoog
Three-dimensional structure of ...
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Proc. Natl. Acad. Sci. USA
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349251
Nanjo
Unique dihydrodiol specific de ...
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Dimeric dihydrodiol dehydrogen ...
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Penning
Non-K-region o-quinones as enz ...
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Biochemistry
28
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Nakagawa
Identification of two dihydrod ...
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1989
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Hara
Isolation from pig lens of two ...
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Smithgall
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Purification and partial chara ...
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Matsuura
Purification and properties of ...
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Biochim. Biophys. Acta
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Regio- and stereospecificity o ...
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Rat liver microsomal 3alpha-hy ...
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1986
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349246
Bolcsak
Purification of mouse liver be ...
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1983
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349247
Vogel
Rat liver cytoplasmic dihydrod ...
Rattus norvegicus
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1980
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