Protein Variants | Comment | Organism |
---|---|---|
additional information | constitutive overexpression of enzyme in 2008 cells leads to induction of cisplatin resistance. In cisplatin-resistant cell-line 2008/C13*, differential expression of enzyme and four more genes is found | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
carboplatin | 50% inhibition at 0.036 mM, 2008 cells, at 0.578 mM, 2008/C13* cells, at 0.097 mM, cells constitutively overexpressing enzyme | Homo sapiens | |
cisplatin | 50% inhibition at 0.002 mM, 2008 cells, at 0.019 mM, 2008/C13* cells, at 0.016 mM, cells constitutively overexpressing enzyme | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
carcinoma cell | cisplatin-sensitive ovarian carcinoma cell line 2008 and its cisplatin-resistant variant 2008/C13* | Homo sapiens | - |
ovary | cisplatin-sensitive ovarian carcinoma cell line 2008 and its cisplatin-resistant variant 2008/C13* | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
500 | - |
substrate 1-indanol, 2008 cells | Homo sapiens |
2000 | - |
substrate 1-indanol, 2008 cells constitutively overexpressing enzyme | Homo sapiens |
6000 | - |
substrate 1-indanol, 2008/C13* cells | Homo sapiens |
7000 | - |
substrate 1-acenaphthol, 2008 cells | Homo sapiens |
26000 | - |
substrate 1-acenaphthol, 2008 cells constitutively overexpressing enzyme | Homo sapiens |
33000 | - |
substrate 1-acenaphthol, 2008/C13* cells | Homo sapiens |
35000 | - |
substrate camphorquinone, 2008 cells | Homo sapiens |
65000 | - |
substrate camphorquinone, 2008/C13* cells | Homo sapiens |
71000 | - |
substrate camphorquinone, 2008 cells constitutively overexpressing enzyme | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-acenaphthol + NADP+ | - |
Homo sapiens | acenaphthylen-1-ol + NADPH | - |
? | |
1-indanol + NADP+ | - |
Homo sapiens | 3H-inden-1-ol + NADPH | - |
? | |
camphorquinone + NADPH | - |
Homo sapiens | ? | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |