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Literature summary for 1.3.1.20 extracted from

  • Hoog, S.S.; Pawlowski, J.E.; Alzari, P.M.; Penning, T.M.; Lewis, M.
    Three-dimensional structure of rat liver 3.alpha-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamily (1994), Proc. Natl. Acad. Sci. USA, 91, 2517-2521.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine enzyme can be used for screening of antiinflammatory potency of drugs Rattus norvegicus

Crystallization (Commentary)

Crystallization (Comment) Organism
vapour diffusion at 22°C in 100 mM sodium citrate, polyethylene glycol 6000 25%, 120 mM ammonium sulfate, pH 5.8, x-ray analysis Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
C170A kinetically similar to wild-type Rattus norvegicus
C217A 4fold increase in Km for 5alpha-androstan-3,17-dione and 2fold increase in Km for NADH Rattus norvegicus
additional information sequence analysis Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibition by nonsteroidal antiinflammatory drugs Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37029
-
1 * 37029, cDNA sequence determination Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus reduces biologically important 3-oxo steroids of the androstane, pregnane, and cholane series ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+ cofactor binding and catalytic triad, alpha/beta-barrel structure Rattus norvegicus
trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+ enzyme is multifunctional: 3alpha-hydroxysteroid dehydrogenase activity, EC 1.1.1.50, dihydrodiol dehydrogenase activity, EC 1.3.1.20, and 9-, 11-, and15-hydroxyprostaglandin dehydrogenase activity, belongs to aldo-keto reductase superfamily Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-keto steroid + NAD(P)H reduces biologically important 3-oxo steroids of the androstane, pregnane, and cholane series Rattus norvegicus 3alpha-hydroxy steroid + NAD(P)+
-
?
additional information reduces biologically important 3-oxo steroids of the androstane, pregnane, and cholane series Rattus norvegicus ?
-
?
additional information oxidation of trans-dihydrodiols of polycyclic hydrocarbons and in this way suppression of formation of anti-diol epoxid carcinogens Rattus norvegicus additional information
-
?

Subunits

Subunits Comment Organism
monomer 1 * 37029, cDNA sequence determination Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADH
-
Rattus norvegicus
NADP+
-
Rattus norvegicus