BRENDA - Enzyme Database show
show all sequences of 1.3.1.20

Three-dimensional structure of rat liver 3.alpha-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamily

Hoog, S.S.; Pawlowski, J.E.; Alzari, P.M.; Penning, T.M.; Lewis, M.; Proc. Natl. Acad. Sci. USA 91, 2517-2521 (1994)

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
enzyme can be used for screening of antiinflammatory potency of drugs
Rattus norvegicus
Crystallization (Commentary)
Crystallization
Organism
vapour diffusion at 22°C in 100 mM sodium citrate, polyethylene glycol 6000 25%, 120 mM ammonium sulfate, pH 5.8, x-ray analysis
Rattus norvegicus
Engineering
Amino acid exchange
Commentary
Organism
C170A
kinetically similar to wild-type
Rattus norvegicus
C217A
4fold increase in Km for 5alpha-androstan-3,17-dione and 2fold increase in Km for NADH
Rattus norvegicus
additional information
sequence analysis
Rattus norvegicus
Inhibitors
Inhibitors
Commentary
Organism
Structure
additional information
inhibition by nonsteroidal antiinflammatory drugs
Rattus norvegicus
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
37029
-
1 * 37029, cDNA sequence determination
Rattus norvegicus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Rattus norvegicus
reduces biologically important 3-oxo steroids of the androstane, pregnane, and cholane series
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Rattus norvegicus
-
-
-
Reaction
Reaction
Commentary
Organism
trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+
cofactor binding and catalytic triad, alpha/beta-barrel structure; enzyme is multifunctional: 3alpha-hydroxysteroid dehydrogenase activity, EC 1.1.1.50, dihydrodiol dehydrogenase activity, EC 1.3.1.20, and 9-, 11-, and15-hydroxyprostaglandin dehydrogenase activity, belongs to aldo-keto reductase superfamily
Rattus norvegicus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3-keto steroid + NAD(P)H
reduces biologically important 3-oxo steroids of the androstane, pregnane, and cholane series
349257
Rattus norvegicus
3alpha-hydroxy steroid + NAD(P)+
-
-
-
?
additional information
reduces biologically important 3-oxo steroids of the androstane, pregnane, and cholane series
349257
Rattus norvegicus
?
-
-
-
-
additional information
oxidation of trans-dihydrodiols of polycyclic hydrocarbons and in this way suppression of formation of anti-diol epoxid carcinogens
349257
Rattus norvegicus
additional information
-
-
-
-
Subunits
Subunits
Commentary
Organism
monomer
1 * 37029, cDNA sequence determination
Rattus norvegicus
Cofactor
Cofactor
Commentary
Organism
Structure
NADH
-
Rattus norvegicus
NADP+
-
Rattus norvegicus
Application (protein specific)
Application
Commentary
Organism
medicine
enzyme can be used for screening of antiinflammatory potency of drugs
Rattus norvegicus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADH
-
Rattus norvegicus
NADP+
-
Rattus norvegicus
Crystallization (Commentary) (protein specific)
Crystallization
Organism
vapour diffusion at 22°C in 100 mM sodium citrate, polyethylene glycol 6000 25%, 120 mM ammonium sulfate, pH 5.8, x-ray analysis
Rattus norvegicus
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
C170A
kinetically similar to wild-type
Rattus norvegicus
C217A
4fold increase in Km for 5alpha-androstan-3,17-dione and 2fold increase in Km for NADH
Rattus norvegicus
additional information
sequence analysis
Rattus norvegicus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
additional information
inhibition by nonsteroidal antiinflammatory drugs
Rattus norvegicus
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
37029
-
1 * 37029, cDNA sequence determination
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Rattus norvegicus
reduces biologically important 3-oxo steroids of the androstane, pregnane, and cholane series
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3-keto steroid + NAD(P)H
reduces biologically important 3-oxo steroids of the androstane, pregnane, and cholane series
349257
Rattus norvegicus
3alpha-hydroxy steroid + NAD(P)+
-
-
-
?
additional information
reduces biologically important 3-oxo steroids of the androstane, pregnane, and cholane series
349257
Rattus norvegicus
?
-
-
-
-
additional information
oxidation of trans-dihydrodiols of polycyclic hydrocarbons and in this way suppression of formation of anti-diol epoxid carcinogens
349257
Rattus norvegicus
additional information
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
monomer
1 * 37029, cDNA sequence determination
Rattus norvegicus
Other publictions for EC 1.3.1.20
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
740358
Liu
Metabolites analysis, metaboli ...
Ruditapes philippinarum
Ecotoxicol. Environ. Saf.
107
251-259
2014
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1
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697571
Chang
Overexpression of dihydrodiol ...
Homo sapiens
Digest. Dis. Sci.
54
342-347
2009
-
1
-
-
-
-
-
-
1
-
-
1
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1
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2
1
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1
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1
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1
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1
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2
1
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684150
Carbone
Structure of monkey dimeric di ...
Macaca fascicularis, Macaca fuscata
Acta Crystallogr. Sect. D
64
532-542
2008
-
-
2
2
30
-
4
26
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-
2
-
2
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-
2
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-
-
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4
2
-
-
-
10
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3
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-
23
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2
3
2
30
-
23
4
-
26
-
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2
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-
2
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-
4
2
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-
10
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686023
Carbone
Structural and functional feat ...
Bos taurus, Macaca fascicularis, Mus musculus, Pongo abelii, Sus scrofa
Cell. Mol. Life Sci.
65
1464-1474
2008
-
-
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1
5
-
8
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2
-
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5
-
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3
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-
15
2
-
-
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-
10
-
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2
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-
10
1
5
-
2
8
-
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2
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3
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-
15
2
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701119
Carbone
Structures of dimeric dihydrod ...
Macaca fascicularis
Proteins Struct. Funct. Genet.
70
176-187
2008
-
-
1
1
3
-
1
-
-
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1
1
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1
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1
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3
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1
2
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1
-
1
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2
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-
1
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1
2
1
3
-
1
1
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-
-
-
1
1
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-
1
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-
3
-
1
2
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-
1
-
1
-
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-
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-
685913
Pan
Dihydrodiol dehydrogenase in d ...
Homo sapiens
Cancer Chemother. Pharmacol.
59
697-702
2007
-
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1
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2
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1
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1
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1
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2
-
-
1
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-
-
-
687141
Wang
Reversal of inflammation-assoc ...
Homo sapiens
Int. J. Cancer
120
2019-2027
2007
1
-
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3
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1
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2
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1
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2
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1
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2
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2
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6
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2
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2
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2
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-
689972
Carbone
-
Structures of dimeric dihydrod ...
Macaca fascicularis
Proteins Struct. Funct. Bioinform.
70
176-187
2007
-
-
1
1
3
-
1
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1
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1
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2
1
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1
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1
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1
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1
1
1
3
-
1
1
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1
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-
-
2
1
-
-
1
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-
-
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-
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-
-
-
671358
Hung
Expression of dihydrodiol dehy ...
Homo sapiens
Anticancer Res.
26
2949-2956
2006
-
1
-
-
1
-
-
-
-
-
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1
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6
-
-
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-
1
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1
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6
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
673371
Cheng
A possible role for dihydrodio ...
Homo sapiens
Environ. Mol. Mutagen.
48
14-21
2006
-
1
-
-
1
-
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-
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1
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3
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1
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1
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3
-
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-
675089
Chow
Expression of dihydrodiol dehy ...
Homo sapiens
J. Dermatol. Sci.
41
205-212
2006
-
1
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-
-
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1
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1
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1
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1
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-
-
-
673903
Chen
Overexpression of dihydrodiol ...
Homo sapiens
Gynecol. Oncol.
97
110-117
2005
-
1
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-
-
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1
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1
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1
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1
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-
655159
Deng
Ubiquitous induction of resist ...
Homo sapiens
Cancer Chemother. Pharmacol.
54
301-307
2004
-
-
-
-
-
-
7
-
-
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-
-
-
1
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-
1
5
-
1
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1
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-
1
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7
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1
5
-
1
-
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-
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-
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-
655236
Seike
Oxidative DNA damage induced b ...
Mus musculus
Chem. Res. Toxicol.
17
1445-1451
2004
-
1
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1
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1
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1
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1
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655744
Wang
Inverse expression of dihydrod ...
Homo sapiens
Int. J. Cancer
111
246-251
2004
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1
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1
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657392
Tang
Hydroxychavicol modulates benz ...
Homo sapiens
Toxicol. Lett.
152
235-243
2004
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1
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656885
Yang
Reduction of dihydrodiol dehyd ...
Homo sapiens
Oncol. Rep.
10
271-276
2003
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1
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1
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1
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1
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349258
El-Kabbani
Crystallization and preliminar ...
Macaca fuscata
Acta Crystallogr. Sect. D
58
163-164
2002
-
-
1
1
-
-
-
-
-
-
-
-
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1
-
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1
1
-
1
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1
1
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1
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1
1
1
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1
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1
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1
1
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-
655321
Higaki
Molecular characterization of ...
Macaca fascicularis, Macaca fuscata fuscata
Drug Metab. Pharmacokinet.
17
348-356
2002
-
-
-
-
-
-
-
10
-
-
2
-
-
4
-
-
-
-
-
2
2
-
19
2
2
-
-
10
2
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
10
-
-
2
-
-
-
-
-
-
2
2
-
19
2
2
-
-
10
2
-
-
-
-
-
-
-
-
-
656043
Deng
Increased expression of dihydr ...
Homo sapiens
J. Biol. Chem.
277
15035-15043
2002
-
-
-
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1
-
2
-
-
-
-
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1
-
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-
-
2
9
-
3
-
-
-
-
-
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-
-
1
-
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-
1
-
1
-
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2
-
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-
-
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-
2
9
-
3
-
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-
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-
286128
Aoki
Identity of dimeric dihydrodio ...
Canis sp., Homo sapiens, Macaca fuscata, Oryctolagus cuniculus, Sus scrofa
Chem. Biol. Interact.
130-132
775-784
2001
-
-
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-
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9
10
-
-
-
-
-
5
-
-
3
1
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Matsuura
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Hara
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Nanjo
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Hoog
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Nakagawa
Identification of two dihydrod ...
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1989
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Hara
Isolation from pig lens of two ...
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Purification and partial chara ...
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Matsuura
Purification and properties of ...
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Biochim. Biophys. Acta
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Rat liver microsomal 3alpha-hy ...
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Bolcsak
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