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Literature summary for 1.3.1.20 extracted from

  • Nakagawa, M.; Tsukada, F.; Nakayama, T.; Matsuura, K.; Hara, A.; Sawada, H.
    Identification of two dihydrodiol dehydrogenases associated with 3(17)alpha-hydroxysteroid dehydrogenase activity in mouse kidney (1989), Biochem. J., 106(4), 633-638.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
17beta-estradiol
-
Mus musculus
5alpha-Androstan-3-beta-ol-17-one
-
Mus musculus
5alpha-Pregnan-3beta-21-one
-
Mus musculus
5beta-androstan-3beta-ol-17-one
-
Mus musculus
5beta-Pregnan-3beta-ol-20-one
-
Mus musculus
Dienstrol
-
Mus musculus
Hexestrol
-
Mus musculus
Stilbestrol
-
Mus musculus
testosterone
-
Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Mus musculus
0.67
-
cis-benzene dihydrodiol NAD+, DD1 Mus musculus
0.77
-
trans-benzene dihydrodiol NADP+, DD1 Mus musculus
0.91
-
cis-benzene dihydrodiol NAD+ Mus musculus
1.28
-
cis-benzene dihydrodiol NADP+, DD3 Mus musculus
1.99
-
cis-benzene dihydrodiol trans-benzene dihydrodiol, NADP+, DD1 Mus musculus
6.78
-
Naphthalene dihydrodiol NADP+ Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Mus musculus 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
39000
-
1 * 39000, kidney, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus metabolic inactivation of dihydrodiols or dihydrodiol epoxides derived from carcinogenic polycylic hydrocarbons ?
-
?
naphthalene dihydrodiol + NAD(P)+ Mus musculus
-
?
-
?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+ Mus musculus
-
catechol + NAD(P)H
-
?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+ Mus musculus
-
catechol + NAD(P)H
-
r

Organism

Organism UniProt Comment Textmining
Mus musculus
-
dihydrodiol dehydrogenase EC 1.3.1.20 and 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 activities reside on a single protein
-
Mus musculus
-
enzyme forms: DD1, DD3
-

Purification (Commentary)

Purification (Comment) Organism
dihydrodiol dehydrogenase EC 1.3.1.20 and 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 activities reside on a single protein Mus musculus
enzyme forms: DD1, DD3 Mus musculus

Reaction

Reaction Comment Organism Reaction ID
trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+ isoform DD3 probably identical with 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 and D-xylose dehydrogenase EC 1.1.1.179 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland low activity Mus musculus
-
heart low activity Mus musculus
-
kidney
-
Mus musculus
-
liver
-
Mus musculus
-
lung low activity Mus musculus
-
testis low activity Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17beta-estradiol + NAD(P)+ isoform DD3: dihydrodiol dehydrogenase EC 1.3.1.20 and 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 activities reside on a single protein Mus musculus ?
-
?
3-keto steroid + NAD(P)H probably reversible reaction Mus musculus 3alpha-hydroxy steroid + NAD(P)+
-
?
3alpha-hydroxy steroid + NADP+
-
Mus musculus 3-keto steroid + NADPH
-
?
4-nitrobenzaldehyde + NAD(P)H
-
Mus musculus 4-nitrobenzylalcohol + NAD(P)+
-
?
alicyclic alcohol + NAD(P)+
-
Mus musculus ?
-
?
camphorquinone + NAD(P)H
-
Mus musculus (1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+
-
?
cis-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
Mus musculus catechol + NAD(P)H
-
r
epitestosterone + NAD(P)+ isoform DD3: dihydrodiol dehydrogenase EC 1.3.1.20 and 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 activities reside on a single protein Mus musculus ?
-
?
glycolithocholic acid + NAD(P)+ NAD+ preferred as cofactor Mus musculus 3-oxo-glycocholanoic acid + NAD(P)H
-
?
additional information metabolic inactivation of dihydrodiols or dihydrodiol epoxides derived from carcinogenic polycylic hydrocarbons Mus musculus ?
-
?
additional information NADP+ or NAD+ as cofactors Mus musculus additional information
-
?
naphthalene dihydrodiol + NAD(P)+
-
Mus musculus ?
-
?
tetrahydrodeoxycorticosterone + NAD(P)+ isoform DD3: dihydrodiol dehydrogenase EC 1.3.1.20 and 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 activities reside on a single protein Mus musculus ?
-
?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
Mus musculus catechol + NAD(P)H
-
?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
Mus musculus catechol + NAD(P)H
-
r
trans-naphthalene dihydrodiol + NAD(P)+
-
Mus musculus ?
-
?

Subunits

Subunits Comment Organism
monomer 1 * 39000, kidney, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
DD
-
Mus musculus
dihydrodiol dehydrogenase
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Mus musculus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
45
-
dihydrodiol dehydrogenase and 3(17)alpha-hydroxysteroid dehydrogenase activity, pH 7.5, 5 min Mus musculus
50
-
dihydrodiol dehydrogenase and 3(17)alpha-hydroxysteroid dehydrogenase activity, pH 7.5, all activity lost Mus musculus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Mus musculus
NADH
-
Mus musculus
NADP+
-
Mus musculus