BRENDA - Enzyme Database show
show all sequences of 1.3.1.20

Identification of two dihydrodiol dehydrogenases associated with 3(17)alpha-hydroxysteroid dehydrogenase activity in mouse kidney

Nakagawa, M.; Tsukada, F.; Nakayama, T.; Matsuura, K.; Hara, A.; Sawada, H.; Biochem. J. 106(4), 633-638 (1989)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
17beta-estradiol
-
Mus musculus
5alpha-Androstan-3-beta-ol-17-one
-
Mus musculus
5alpha-Pregnan-3beta-21-one
-
Mus musculus
5beta-androstan-3beta-ol-17-one
-
Mus musculus
5beta-Pregnan-3beta-ol-20-one
-
Mus musculus
Dienstrol
-
Mus musculus
Hexestrol
-
Mus musculus
Stilbestrol
-
Mus musculus
testosterone
-
Mus musculus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
-
Mus musculus
0.67
-
cis-benzene dihydrodiol
NAD+, DD1
Mus musculus
0.77
-
trans-benzene dihydrodiol
NADP+, DD1
Mus musculus
0.91
-
cis-benzene dihydrodiol
NAD+
Mus musculus
1.28
-
cis-benzene dihydrodiol
NADP+, DD3
Mus musculus
1.99
-
cis-benzene dihydrodiol
trans-benzene dihydrodiol, NADP+, DD1
Mus musculus
6.78
-
Naphthalene dihydrodiol
NADP+
Mus musculus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
-
Mus musculus
5737
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
39000
-
1 * 39000, kidney, SDS-PAGE
Mus musculus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Mus musculus
metabolic inactivation of dihydrodiols or dihydrodiol epoxides derived from carcinogenic polycylic hydrocarbons
?
-
-
-
naphthalene dihydrodiol + NAD(P)+
Mus musculus
-
?
-
-
?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
Mus musculus
-
catechol + NAD(P)H
-
-
?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
Mus musculus
-
catechol + NAD(P)H
-
-
r
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mus musculus
-
dihydrodiol dehydrogenase EC 1.3.1.20 and 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 activities reside on a single protein; enzyme forms: DD1, DD3
-
Purification (Commentary)
Commentary
Organism
dihydrodiol dehydrogenase EC 1.3.1.20 and 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 activities reside on a single protein; enzyme forms: DD1, DD3
Mus musculus
Reaction
Reaction
Commentary
Organism
trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+
isoform DD3 probably identical with 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 and D-xylose dehydrogenase EC 1.1.1.179
Mus musculus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
adrenal gland
low activity
Mus musculus
-
heart
low activity
Mus musculus
-
kidney
-
Mus musculus
-
liver
-
Mus musculus
-
lung
low activity
Mus musculus
-
testis
low activity
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
17beta-estradiol + NAD(P)+
isoform DD3: dihydrodiol dehydrogenase EC 1.3.1.20 and 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 activities reside on a single protein
349239
Mus musculus
?
-
-
-
?
3-keto steroid + NAD(P)H
probably reversible reaction
349239
Mus musculus
3alpha-hydroxy steroid + NAD(P)+
-
-
-
?
3alpha-hydroxy steroid + NADP+
-
349239
Mus musculus
3-keto steroid + NADPH
-
-
-
?
4-nitrobenzaldehyde + NAD(P)H
-
349239
Mus musculus
4-nitrobenzylalcohol + NAD(P)+
-
-
-
?
alicyclic alcohol + NAD(P)+
-
349239
Mus musculus
?
-
-
-
?
camphorquinone + NAD(P)H
-
349239
Mus musculus
(1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+
-
-
-
?
cis-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
349239
Mus musculus
catechol + NAD(P)H
-
-
-
r
epitestosterone + NAD(P)+
isoform DD3: dihydrodiol dehydrogenase EC 1.3.1.20 and 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 activities reside on a single protein
349239
Mus musculus
?
-
-
-
?
glycolithocholic acid + NAD(P)+
NAD+ preferred as cofactor
349239
Mus musculus
3-oxo-glycocholanoic acid + NAD(P)H
-
-
-
?
additional information
metabolic inactivation of dihydrodiols or dihydrodiol epoxides derived from carcinogenic polycylic hydrocarbons
349239
Mus musculus
?
-
-
-
-
additional information
NADP+ or NAD+ as cofactors
349239
Mus musculus
additional information
-
-
-
-
naphthalene dihydrodiol + NAD(P)+
-
349239
Mus musculus
?
-
-
-
?
tetrahydrodeoxycorticosterone + NAD(P)+
isoform DD3: dihydrodiol dehydrogenase EC 1.3.1.20 and 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 activities reside on a single protein
349239
Mus musculus
?
-
-
-
?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
349239
Mus musculus
catechol + NAD(P)H
-
-
-
?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
349239
Mus musculus
catechol + NAD(P)H
-
-
-
r
trans-naphthalene dihydrodiol + NAD(P)+
-
349239
Mus musculus
?
-
-
-
?
Subunits
Subunits
Commentary
Organism
monomer
1 * 39000, kidney, SDS-PAGE
Mus musculus
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
25
-
assay at
Mus musculus
Temperature Stability [°C]
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
45
-
dihydrodiol dehydrogenase and 3(17)alpha-hydroxysteroid dehydrogenase activity, pH 7.5, 5 min
Mus musculus
50
-
dihydrodiol dehydrogenase and 3(17)alpha-hydroxysteroid dehydrogenase activity, pH 7.5, all activity lost
Mus musculus
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
-
Mus musculus
NADH
-
Mus musculus
NADP+
-
Mus musculus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
-
Mus musculus
NADH
-
Mus musculus
NADP+
-
Mus musculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
17beta-estradiol
-
Mus musculus
5alpha-Androstan-3-beta-ol-17-one
-
Mus musculus
5alpha-Pregnan-3beta-21-one
-
Mus musculus
5beta-androstan-3beta-ol-17-one
-
Mus musculus
5beta-Pregnan-3beta-ol-20-one
-
Mus musculus
Dienstrol
-
Mus musculus
Hexestrol
-
Mus musculus
Stilbestrol
-
Mus musculus
testosterone
-
Mus musculus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
-
Mus musculus
0.67
-
cis-benzene dihydrodiol
NAD+, DD1
Mus musculus
0.77
-
trans-benzene dihydrodiol
NADP+, DD1
Mus musculus
0.91
-
cis-benzene dihydrodiol
NAD+
Mus musculus
1.28
-
cis-benzene dihydrodiol
NADP+, DD3
Mus musculus
1.99
-
cis-benzene dihydrodiol
trans-benzene dihydrodiol, NADP+, DD1
Mus musculus
6.78
-
Naphthalene dihydrodiol
NADP+
Mus musculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
-
Mus musculus
5737
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
39000
-
1 * 39000, kidney, SDS-PAGE
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Mus musculus
metabolic inactivation of dihydrodiols or dihydrodiol epoxides derived from carcinogenic polycylic hydrocarbons
?
-
-
-
naphthalene dihydrodiol + NAD(P)+
Mus musculus
-
?
-
-
?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
Mus musculus
-
catechol + NAD(P)H
-
-
?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
Mus musculus
-
catechol + NAD(P)H
-
-
r
Purification (Commentary) (protein specific)
Commentary
Organism
dihydrodiol dehydrogenase EC 1.3.1.20 and 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 activities reside on a single protein; enzyme forms: DD1, DD3
Mus musculus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
adrenal gland
low activity
Mus musculus
-
heart
low activity
Mus musculus
-
kidney
-
Mus musculus
-
liver
-
Mus musculus
-
lung
low activity
Mus musculus
-
testis
low activity
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
17beta-estradiol + NAD(P)+
isoform DD3: dihydrodiol dehydrogenase EC 1.3.1.20 and 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 activities reside on a single protein
349239
Mus musculus
?
-
-
-
?
3-keto steroid + NAD(P)H
probably reversible reaction
349239
Mus musculus
3alpha-hydroxy steroid + NAD(P)+
-
-
-
?
3alpha-hydroxy steroid + NADP+
-
349239
Mus musculus
3-keto steroid + NADPH
-
-
-
?
4-nitrobenzaldehyde + NAD(P)H
-
349239
Mus musculus
4-nitrobenzylalcohol + NAD(P)+
-
-
-
?
alicyclic alcohol + NAD(P)+
-
349239
Mus musculus
?
-
-
-
?
camphorquinone + NAD(P)H
-
349239
Mus musculus
(1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+
-
-
-
?
cis-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
349239
Mus musculus
catechol + NAD(P)H
-
-
-
r
epitestosterone + NAD(P)+
isoform DD3: dihydrodiol dehydrogenase EC 1.3.1.20 and 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 activities reside on a single protein
349239
Mus musculus
?
-
-
-
?
glycolithocholic acid + NAD(P)+
NAD+ preferred as cofactor
349239
Mus musculus
3-oxo-glycocholanoic acid + NAD(P)H
-
-
-
?
additional information
metabolic inactivation of dihydrodiols or dihydrodiol epoxides derived from carcinogenic polycylic hydrocarbons
349239
Mus musculus
?
-
-
-
-
additional information
NADP+ or NAD+ as cofactors
349239
Mus musculus
additional information
-
-
-
-
naphthalene dihydrodiol + NAD(P)+
-
349239
Mus musculus
?
-
-
-
?
tetrahydrodeoxycorticosterone + NAD(P)+
isoform DD3: dihydrodiol dehydrogenase EC 1.3.1.20 and 3(17)alpha-hydroxysteroid dehydrogenase EC 1.1.1.59 activities reside on a single protein
349239
Mus musculus
?
-
-
-
?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
349239
Mus musculus
catechol + NAD(P)H
-
-
-
?
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
-
349239
Mus musculus
catechol + NAD(P)H
-
-
-
r
trans-naphthalene dihydrodiol + NAD(P)+
-
349239
Mus musculus
?
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
monomer
1 * 39000, kidney, SDS-PAGE
Mus musculus
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
25
-
assay at
Mus musculus
Temperature Stability [°C] (protein specific)
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
45
-
dihydrodiol dehydrogenase and 3(17)alpha-hydroxysteroid dehydrogenase activity, pH 7.5, 5 min
Mus musculus
50
-
dihydrodiol dehydrogenase and 3(17)alpha-hydroxysteroid dehydrogenase activity, pH 7.5, all activity lost
Mus musculus
Other publictions for EC 1.3.1.20
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
740358
Liu
Metabolites analysis, metaboli ...
Ruditapes philippinarum
Ecotoxicol. Environ. Saf.
107
251-259
2014
-
-
-
-
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-
-
-
-
-
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1
-
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-
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2
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1
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1
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1
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2
-
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1
-
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-
-
-
-
-
-
-
-
-
-
-
-
697571
Chang
Overexpression of dihydrodiol ...
Homo sapiens
Digest. Dis. Sci.
54
342-347
2009
-
1
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
2
1
-
1
-
-
-
-
-
-
-
-
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1
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-
-
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1
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1
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2
1
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1
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-
-
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-
-
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684150
Carbone
Structure of monkey dimeric di ...
Macaca fascicularis, Macaca fuscata
Acta Crystallogr. Sect. D
64
532-542
2008
-
-
2
2
30
-
4
26
-
-
-
2
-
2
-
-
2
-
-
-
-
-
4
2
-
-
-
10
-
-
-
3
-
-
23
-
-
2
3
2
30
-
23
4
-
26
-
-
-
2
-
-
-
2
-
-
-
-
4
2
-
-
-
10
-
-
-
-
-
-
-
-
-
-
686023
Carbone
Structural and functional feat ...
Bos taurus, Macaca fascicularis, Mus musculus, Pongo abelii, Sus scrofa
Cell. Mol. Life Sci.
65
1464-1474
2008
-
-
-
1
5
-
8
-
-
2
-
-
-
5
-
-
-
-
-
3
-
-
15
2
-
-
-
-
-
-
-
10
-
-
2
-
-
-
10
1
5
-
2
8
-
-
-
2
-
-
-
-
-
-
-
3
-
-
15
2
-
-
-
-
-
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-
-
-
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-
-
-
-
701119
Carbone
Structures of dimeric dihydrod ...
Macaca fascicularis
Proteins Struct. Funct. Genet.
70
176-187
2008
-
-
1
1
3
-
1
-
-
-
1
1
-
1
-
-
1
-
-
-
3
-
1
2
-
-
1
-
1
-
-
2
-
-
1
-
-
1
2
1
3
-
1
1
-
-
-
-
1
1
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-
1
-
-
3
-
1
2
-
-
1
-
1
-
-
-
-
-
-
-
-
-
685913
Pan
Dihydrodiol dehydrogenase in d ...
Homo sapiens
Cancer Chemother. Pharmacol.
59
697-702
2007
-
-
-
-
-
-
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1
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2
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1
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1
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1
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2
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1
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-
-
-
-
-
-
-
-
-
-
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687141
Wang
Reversal of inflammation-assoc ...
Homo sapiens
Int. J. Cancer
120
2019-2027
2007
1
-
-
-
-
-
3
-
-
-
1
-
-
2
-
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-
-
1
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2
-
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-
-
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1
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2
-
-
2
-
-
-
-
6
-
-
-
-
2
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689972
Carbone
-
Structures of dimeric dihydrod ...
Macaca fascicularis
Proteins Struct. Funct. Bioinform.
70
176-187
2007
-
-
1
1
3
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
1
-
-
1
-
-
-
-
1
-
-
1
-
-
1
1
1
3
-
1
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
671358
Hung
Expression of dihydrodiol dehy ...
Homo sapiens
Anticancer Res.
26
2949-2956
2006
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
1
-
-
-
1
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-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673371
Cheng
A possible role for dihydrodio ...
Homo sapiens
Environ. Mol. Mutagen.
48
14-21
2006
-
1
-
-
1
-
-
-
-
-
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1
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3
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1
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1
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3
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675089
Chow
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Overexpression of dihydrodiol ...
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Oxidative DNA damage induced b ...
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Inverse expression of dihydrod ...
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657392
Tang
Hydroxychavicol modulates benz ...
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Reduction of dihydrodiol dehyd ...
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349258
El-Kabbani
Crystallization and preliminar ...
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655321
Higaki
Molecular characterization of ...
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2002
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Increased expression of dihydr ...
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286128
Aoki
Identity of dimeric dihydrodio ...
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349250
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Site-directed mutagenesis stud ...
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Asada
Roles of His-79 and Tyr-180 of ...
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349252
Kume
Characterization of a novel va ...
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Burczynski
Expression and characterizatio ...
Homo sapiens
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349261
Matsuura
Roles of the C-terminal domain ...
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349262
Matsuura
Identification of amino acid r ...
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349263
Bennett
Steroid recognition and regula ...
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5
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349259
Hara
Relationship of human liver di ...
Homo sapiens
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349253
Miyabe
Kinetic studies of the inhibit ...
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Deyashiki
Expression and kinetic propert ...
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349256
Nanjo
Enzymic characterization of a ...
Bos taurus
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1995
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Hoog
Three-dimensional structure of ...
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Non-K-region o-quinones as enz ...
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28
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Nakagawa
Identification of two dihydrod ...
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Hara
Isolation from pig lens of two ...
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