Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.1.16 extracted from

  • Vitturi, D.A.; Chen, C.S.; Woodcock, S.R.; Salvatore, S.R.; Bonacci, G.; Koenitzer, J.R.; Stewart, N.A.; Wakabayashi, N.; Kensler, T.W.; Freeman, B.A.; Schopfer, F.J.
    Modulation of nitro-fatty acid signaling: prostaglandin reductase-1 is a nitroalkene reductase (2013), J. Biol. Chem., 288, 25626-25637.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in HEK-293T cell Homo sapiens
expression in HEK-293T cell Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000085
-
(9E)-9-nitrooctadec-9-enoic acid pH 7.0, temperature not specified in the publication Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(9E)-9-nitrooctadec-9-enoic acid + NADPH + H+
-
Homo sapiens 9-nitrostearic acid + NADP+
-
r
10-nitrooctadec-9-enoic acid + NADPH + H+
-
Homo sapiens 10-nitrostearic acid + NADP+
-
?
10-nitrooctadec-9-enoic acid + NADPH + H+
-
Rattus norvegicus 10-nitrostearic acid + NADP+
-
?
9-nitrooctadec-9-enoic acid + NADPH + H+
-
Homo sapiens 9-nitrostearic acid + NADP+
-
?
9-nitrooctadec-9-enoic acid + NADPH + H+
-
Rattus norvegicus 9-nitrostearic acid + NADP+
-
?
additional information enzyme is specific for the reduction of the nitroalkene moiety, yielding saturated non-electrophilic products Homo sapiens ?
-
?
additional information enzyme is specific for the reduction of the nitroalkene moiety, yielding saturated non-electrophilic products Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
prostaglandin reductase-1
-
Homo sapiens
prostaglandin reductase-1
-
Rattus norvegicus
PtGR-1
-
Homo sapiens
PtGR-1
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADH NADPH is preferred over NADH Homo sapiens
NADH NADPH is preferred over NADH Rattus norvegicus
NADPH NADPH is preferred over NADH Homo sapiens
NADPH NADPH is preferred over NADH Rattus norvegicus

General Information

General Information Comment Organism
physiological function overexpression of prostaglandin reductase-1 in HEK-293T cells promotes nitroalkene metabolism to inactive nitroalkanes, an effect that abrogates the Nrf2-dependent induction of heme oxygenase-1 expression by nitro-oleic acid Homo sapiens
physiological function overexpression of prostaglandin reductase-1 in HEK-293T cells promotes nitroalkene metabolism to inactive nitroalkanes, an effect that abrogates the Nrf2-dependent induction of heme oxygenase-1 expression by nitro-oleic acid Rattus norvegicus

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
81
-
(9E)-9-nitrooctadec-9-enoic acid pH 7.0, temperature not specified in the publication Homo sapiens