Literature summary for 1.3.1.14 extracted from

Mohsen, A.W.; Rigby, S.E.; Jensen, K.F.; Munro, A.W.; Scrutton, N.S.
Thermodynamic basis of electron transfer in dihydroorotate dehydrogenase B from Lactococcus lactis: analysis by potentiometry, EPR spectroscopy, and ENDOR spectroscopy (2004), Biochemistry, 43, 6498-6510.

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Organism

Organism	UniProt	Comment	Textmining
Lactococcus lactis	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
(S)-dihydroorotate + NAD+ = orotate + NADH + H+	detailed thermodynamic analysis, midpoint reduction potential of 2Fe-2S center -212 mV, midpoint reduction potential of FMN -298 mV	Lactococcus lactis	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dihydroorotate + NAD+	-	Lactococcus lactis	orotate + NADH + H+	-	?

Cofactor

Cofactor	Comment	Organism	Structure
FAD	-	Lactococcus lactis
FMN	-	Lactococcus lactis
iron-sulfur centre	2FE-2S cluster	Lactococcus lactis

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Release 2023.1 (January 2023)