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Literature summary for 1.3.1.12 extracted from
- Probing the overlap of chorismate mutase and prephenate dehydrogenase sites in the escherichia coli T-protein: a dehydrogenase-selective inhibitor (2002), Bioorg. Med. Chem. Lett., 12, 929-931.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-hydroxyphenylacetate | - |
Escherichia coli |  |
| 5,6-dihydro-5,6-dihydroxychorismate | - |
Escherichia coli | |
| adamantane-1,3-diacetate | - |
Escherichia coli | |
| adamantane-1-acetate | - |
Escherichia coli | |
| adamantane-1-carboxylate | - |
Escherichia coli | |
| adamantane-1-phosphonate | - |
Escherichia coli | |
| chorismate-5,6-epoxide | - |
Escherichia coli | |
| trans-2,3-pleiadanedicarboxylic acid | i.e. diacid, 50% inhibition at 0.25 mM, inhibits competitively the prephenate dehydrogenase activity, but not the chorismate mutase activity of the enzyme | Escherichia coli | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| prephenate + NAD+ | Escherichia coli | second step in the biosynthesis of L-tyrosine | 4-hydroxyphenylpyruvate + CO2 + NADH | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH + H+ | the T-protein is a bifunctional enzyme showing chorismate mutase, EC 5.4.99.5, and prephenate dehydrogenase activities at two separate active sites | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| prephenate + NAD+ | - |
Escherichia coli | 4-hydroxyphenylpyruvate + CO2 + NADH | - |
? | |
| prephenate + NAD+ | second step in the biosynthesis of L-tyrosine | Escherichia coli | 4-hydroxyphenylpyruvate + CO2 + NADH | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| T-protein | - |
Escherichia coli |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Escherichia coli |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.8 | - |
assay at | Escherichia coli |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Escherichia coli | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.11 | - |
5,6-dihydro-5,6-dihydroxychorismate | pH 7.8, 37°C | Escherichia coli | |
| 0.13 | - |
adamantane-1-acetate | pH 7.8, 37°C | Escherichia coli | |
| 0.13 | - |
chorismate-5,6-epoxide | pH 7.8, 37°C | Escherichia coli | |
| 0.14 | - |
adamantane-1-phosphonate | pH 7.8, 37°C | Escherichia coli | |
| 0.15 | - |
adamantane-1,3-diacetate | pH 7.8, 37°C | Escherichia coli | |
| 0.17 | - |
2-hydroxyphenylacetate | pH 7.8, 37°C | Escherichia coli | |
| 0.21 | - |
trans-2,3-pleiadanedicarboxylic acid | pH 7.8, 37°C | Escherichia coli | |
| 0.31 | - |
adamantane-1-carboxylate | pH 7.8, 37°C | Escherichia coli | |
| 0.59 | - |
CKTENMQSC | pH 7.8, 37°C | Escherichia coli | |
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