Any feedback?
Literature summary for 1.3.1.10 extracted from
- Aquastatin A, a new inhibitor of enoyl-acyl carrier protein reductase from Sporothrix sp. FN611 (2009), Biol. Pharm. Bull., 32, 2061-2064.
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | the bacterial enoyl-ACP reductase is a target for antibacterial drug development | Staphylococcus aureus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| aquastatin A | a natural inhibitor from the fungus Sporothrix sp. strain FN611, mixed-type inhibition against FabI with respect to the substrate trans-2-octenoyl N-acetylcysteamine and NADPH, prevents the growth of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus with minimum inhibitory concentration of 0.016-0.032 mg/ml, overview | Staphylococcus aureus |  |
| degalactosylated aquastatin A | a natural inhibitor from the fungus Sporothrix sp. strain FN611 | Staphylococcus aureus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Staphylococcus aureus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | activity measurement by reduction of the trans-2-octenoyl N-acetylcysteamine as substrate and NADPH as cofactor | Staphylococcus aureus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| enoyl-ACP reductase | - |
Staphylococcus aureus |
| enoyl-acyl carrier protein reductase | - |
Staphylococcus aureus |
| FabI | - |
Staphylococcus aureus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Staphylococcus aureus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
assay at | Staphylococcus aureus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Staphylococcus aureus | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0014 | - |
aquastatin A | pH 6.5, 30°C, versus NADPH | Staphylococcus aureus | |
| 0.00161 | - |
aquastatin A | pH 6.5, 30°C, versus trans-2-octenoyl N-acetylcysteamine | Staphylococcus aureus | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0032 | - |
FabI, pH 6.5, 30°C | Staphylococcus aureus | aquastatin A | |
| 0.0034 | - |
FabI, pH 6.5, 30°C | Staphylococcus aureus | degalactosylated aquastatin A | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2026.1 (March 2026)
Legal
Curated at
Member of
![DSMZ Digital Diversity]()
![Global Core Biodata Resource]()
![ELIXIR Core Data Resource]()
![German Network for Bioinformatics Infrastructure]()
