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Literature summary for 1.3.1.1 extracted from

  • Baumel-Alterzon, S.; Weber, C.; Guillen, N.; Ankri, S.
    Identification of dihydropyrimidine dehydrogenase as a virulence factor essential for the survival of Entamoeba histolytica in glucose-poor environments (2013), Cell. Microbiol., 15, 130-144.
    View publication on PubMed
Search for more literature for 1.3.1.1

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Entamoeba histolytica the enzyme does not use NADPH as cosubstrate ?
-
 ?
additional information Entamoeba histolytica HM1:IMSS the enzyme does not use NADPH as cosubstrate ?
-
 ?
thymine + NADH + H+ Entamoeba histolytica
-
 5,6-dihydrothymine + NAD+
-
 ?
thymine + NADH + H+ Entamoeba histolytica HM1:IMSS
-
 5,6-dihydrothymine + NAD+
-
 ?
uracil + NADH + H+ Entamoeba histolytica
-
 5,6-dihydrouracil + NAD+
-
 ?
uracil + NADH + H+ Entamoeba histolytica HM1:IMSS
-
 5,6-dihydrouracil + NAD+
-
 ?

Organism

Organism UniProt Comment Textmining
Entamoeba histolytica
-
-
-
Entamoeba histolytica HM1:IMSS
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
trophozoite
-
 Entamoeba histolytica
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme does not use NADPH as cosubstrate Entamoeba histolytica ?
-
 ?
additional information the enzyme does not use NADPH as cosubstrate Entamoeba histolytica HM1:IMSS ?
-
 ?
thymine + NADH + H+
-
 Entamoeba histolytica 5,6-dihydrothymine + NAD+
-
 ?
thymine + NADH + H+
-
 Entamoeba histolytica HM1:IMSS 5,6-dihydrothymine + NAD+
-
 ?
uracil + NADH + H+
-
 Entamoeba histolytica 5,6-dihydrouracil + NAD+
-
 ?
uracil + NADH + H+
-
 Entamoeba histolytica HM1:IMSS 5,6-dihydrouracil + NAD+
-
 ?

Synonyms

Synonyms Comment Organism
DPD
-
 Entamoeba histolytica

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Entamoeba histolytica

Expression

Organism Comment Expression
Entamoeba histolytica enzyme expression is upregulated 3.8-fold in glucose-starved trophozoites up

General Information

General Information Comment Organism
physiological function the enzyme is essential for the adaption of Entamoeba histolytica to long-term glucose starvation Entamoeba histolytica