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Literature summary for 1.3.1.1 extracted from
- Increased dihydropyrimidine dehydrogenase activity associated with mild toxicity in patients treated with 5-fluorouracil and leucovorin (2007), Eur. J. Cancer, 43, 459-465.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| leucovorin | - |
Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| buccal mucosa | - |
Homo sapiens | - |
| peripheral blood mononuclear cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-fluorouracil + NADH + H+ | - |
Homo sapiens | 5-fluoro-5,6-dihydrouracil + NAD+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dihydropyrimidine dehydrogenase | - |
Homo sapiens |
| DPD | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Homo sapiens | |
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