Any feedback?
Literature summary for 1.3.1.1 extracted from
- Reductive Degradation of pyrimidines. III. purification and properties of dihydrouracil dehydrogenase (1957), J. Biol. Chem., 227, 693-700.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| uracil + NAD(P)H + H+ | Clostridium uracilicum | reductive pathway of uracil degradation | 5,6-dihydrouracil + NAD(P)+ | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Clostridium uracilicum | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Clostridium uracilicum |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Clostridium uracilicum |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| uracil + NAD(P)H + H+ | high specificity for uracil | Clostridium uracilicum | 5,6-dihydrouracil + NAD(P)+ | - |
r | |
| uracil + NAD(P)H + H+ | reductive pathway of uracil degradation | Clostridium uracilicum | 5,6-dihydrouracil + NAD(P)+ | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 7.8 | uracil reduction | Clostridium uracilicum |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 8.2 | pH 6.5: 33.6% of activity maximum, pH 8.2: 59% of activity maximum | Clostridium uracilicum |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | specific for, no reaction with NADPH | Clostridium uracilicum | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
