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Literature summary for 1.21.99.4 extracted from

  • Poplawski, P.; Rybicka, B.; Boguslawska, J.; Rodzik, K.; Visser, T.J.; Nauman, A.; Piekielko-Witkowska, A.
    Induction of type 1 iodothyronine deiodinase expression inhibits proliferation and migration of renal cancer cells (2017), Mol. Cell. Endocrinol., 442, 58-67 .
    View publication on PubMed
Search for more literature for 1.21.99.4

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-thyroxine + reduced acceptor Homo sapiens
-
 3,3',5-triiodo-L-thyronine + iodide + acceptor + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
KIJ-265T cell
-
 Homo sapiens
-
KIJ-308T cell
-
 Homo sapiens
-
renal cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-thyroxine + reduced acceptor
-
 Homo sapiens 3,3',5-triiodo-L-thyronine + iodide + acceptor + H+
-
 ?

Subunits

Subunits Comment Organism
? x * 28000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
DIO1
-
 Homo sapiens
type 1 iodothyronine deiodinase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme loss contributes to renal carcinogenesis Homo sapiens
physiological function enzyme overexpression inhibits migration of renal cancer cells. Induction of DIO1 expression in KIJ265T cells leads to significantly decreased cellular proliferation and affects the expression of cell cycle genes, inhibiting the expression of genes that stimulate G1-to-S transition (e.g. cyclin E1) while stimulating the expression of cell cycle repressor E2F Homo sapiens