Activating Compound | Comment | Organism | Structure |
---|---|---|---|
(Bu)2cAMP | significantly stimulates deiodinating activity in TT cells | Homo sapiens | |
DEX | - |
Homo sapiens | |
forskolin | significantly stimulates deiodinating activity in TT cells | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000023 | - |
L-thyroxine | neoplastic tissue, apparent Km | Homo sapiens | |
0.0000026 | - |
L-thyroxine | TT cell, apparent Km | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-thyroxine + AH2 | Homo sapiens | - |
3,5,3'-triiodo-L-thyronine + iodide + A + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
medullary thyroid carcinoma cell | - |
Homo sapiens | - |
medullary thyroid carcinoma cell line | - |
Homo sapiens | - |
TT cell | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00000000041 | - |
medullary thyroid carcinoma | Homo sapiens |
0.00000000043 | - |
normal thyroid tissue | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-thyroxine + AH2 | - |
Homo sapiens | 3,5,3'-triiodo-L-thyronine + iodide + A + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
type 2 iodothyronine deiodinase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
activity assay | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.9 | - |
activity assay | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | 3,5,3'-triiodothyronine decreases mRNA levels in TT cell, addition of thyroxine or 3,3',5'-triiodothyronine decreases the deiodinating activity | down |