Inhibitors | Comment | Organism | Structure |
---|---|---|---|
propylthiouracil | D1 inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-thyroxine + AH2 | Homo sapiens | - |
3,5,3'-triiodo-L-thyronine + iodide + A + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
parenchyma of thyroid gland | thyroid tissue samples are collected from five patients, three affected by toxic nodule, and from areas of normal thyroid parenchyma from five patients undergoing total thyroidectomy for thyroid cancer | Homo sapiens | - |
thyroid gland | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0000000058 | - |
normal tissues | Homo sapiens |
0.0000000286 | - |
normal tissues | Homo sapiens |
0.0000000429 | - |
McCune-Albright syndrome patients | Homo sapiens |
0.0000000543 | - |
toxic adenoma patient | Homo sapiens |
0.0000000714 | - |
toxic adenoma patient | Homo sapiens |
0.0000001857 | - |
McCune-Albright syndrome patients | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-thyroxine + AH2 | - |
Homo sapiens | 3,5,3'-triiodo-L-thyronine + iodide + A + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
D1 5'-deiodinase | - |
Homo sapiens |
D2 5'-deiodinase | - |
Homo sapiens |
type 1 5'-deiodinase | - |
Homo sapiens |
type 2 5'-deiodinase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | 5'-deiodinase is increased in McCune-Albright syndrome-associated hyperthyroidism pathogenesis | up |