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Literature summary for 1.21.99.4 extracted from
- Biochemical and molecular biological evidence for the presence of type II iodothyronine deiodinase in mouse mammary gland (2000), Mol. Cell. Endocrinol., 160, 173-181.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| aurothioglucose | - |
Mus musculus |  |
| additional information | no inhibition by propylthiouracil | Mus musculus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000044 | - |
L-thyroxine | - |
Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-thyroxine + electron acceptor | Mus musculus | the enzyme is regulated at the pretranslational level | 3,3',5-triiodothyronine + iodide + reduced electron acceptor | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q9Z1Y9 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| colon | low level of activity | Mus musculus | - |
| duodenum | low level of activity | Mus musculus | - |
| heart | low level of activity | Mus musculus | - |
| kidney | low level of activity | Mus musculus | - |
| liver | low level of activity | Mus musculus | - |
| lung | low level of activity | Mus musculus | - |
| mammary gland | - |
Mus musculus | - |
| prostate | low level of activity | Mus musculus | - |
| testis | low level of activity | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-thyroxine + electron acceptor | - |
Mus musculus | 3,3',5-triiodothyronine + iodide + reduced electron acceptor | - |
? | |
| L-thyroxine + electron acceptor | the enzyme is regulated at the pretranslational level | Mus musculus | 3,3',5-triiodothyronine + iodide + reduced electron acceptor | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| type II iodothyronine deiodinase | - |
Mus musculus |
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Release 2023.1 (January 2023)
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