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Literature summary for 1.21.99.4 extracted from

  • Osuna, C.; Orta, J.M.; Rubio, A.; Molinero, P.; Guerrero, J.M.
    Thyroxine type II 5'-deiodinase activity in pineal and harderian glands is enhanced by hypothyroidism but is independent of serum thyroxine concentrations during hyperthyroidism (1993), Int. J. Biochem., 25, 1041-1046.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information hypothyroidism enhances type II activity and decreases type I activity Rattus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-thyroxine + AH2 Rattus sp. thyronine 5'-deiodinase type II 3,3',5-triiodothyronine + iodide + A + H+
-
?

Organism

Organism UniProt Comment Textmining
Rattus sp.
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-
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Source Tissue

Source Tissue Comment Organism Textmining
brain thyronine 5'-deiodinase type II Rattus sp.
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brown adipose tissue thyronine 5'-deiodinase type II Rattus sp.
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harderian gland thyronine 5'-deiodinase type II Rattus sp.
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hypophysis thyronine 5'-deiodinase type II Rattus sp.
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pineal gland thyronine 5'-deiodinase type II Rattus sp.
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-thyroxine + AH2 thyronine 5'-deiodinase type II Rattus sp. 3,3',5-triiodothyronine + iodide + A + H+
-
?
L-thyroxine + AH2 type II Rattus sp. 3,3',5'-triiodothyronine + iodide + A + H+
-
?