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Literature summary for 1.21.99.4 extracted from

  • Santini, F.; Chopra, I.J.; Hurd, R.E.; Chua Teco, G.N.
    A study of the characteristics of hepatic iodothyronine 5'-monodeiodinase in various vertebrate species (1992), Endocrinology, 131, 830-834.
    View publication on PubMed
Search for more literature for 1.21.99.4

Inhibitors

Inhibitors Comment Organism Structure
aurothioglucose type I, selenium-containing enzyme, competitive Bos taurus
aurothioglucose type I, selenium-containing enzyme, competitive Cavia porcellus
aurothioglucose type I, selenium-containing enzyme, competitive Gallus gallus
aurothioglucose type I, selenium-containing enzyme, competitive Homo sapiens
aurothioglucose type I, selenium-containing enzyme, competitive Mus musculus
aurothioglucose type I, selenium-containing enzyme, competitive Ovis aries
aurothioglucose type I, selenium-containing enzyme, competitive Rattus sp.
aurothioglucose type I, selenium-containing enzyme, competitive Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.21
-
 3,3',5'-triiodothyronine type I Rattus sp.
0.21
-
 3,3',5'-triiodothyronine DTT 10 mM Rattus sp.
0.24
-
 3,3',5'-triiodothyronine DTT 10 mM Bos taurus
0.24
-
 3,3',5'-triiodothyronine type I, liver Bos taurus
0.28
-
 3,3',5'-triiodothyronine DTT 10 mM Mus musculus
0.28
-
 3,3',5'-triiodothyronine type I, liver Mus musculus
0.33
-
 3,3',5'-triiodothyronine DTT 10 mM Sus scrofa
0.33
-
 3,3',5'-triiodothyronine type I, liver Sus scrofa
0.51
-
 3,3',5'-triiodothyronine DTT 10 mM Cavia porcellus
0.51
-
 3,3',5'-triiodothyronine type I, liver Cavia porcellus
0.66
-
 3,3',5'-triiodothyronine DTT 10 mM Gallus gallus
0.66
-
 3,3',5'-triiodothyronine type I,l iver Gallus gallus
0.69
-
 3,3',5'-triiodothyronine DTT 10 mM Ovis aries
0.69
-
 3,3',5'-triiodothyronine type I, liver Ovis aries
0.7
-
 3,3',5'-triiodothyronine DTT 10 mM Homo sapiens
0.7
-
 3,3',5'-triiodothyronine type I, liver Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3,3',5'-triiodothyronine + AH2 Gallus gallus
-
 3,3'-diiodothyronine + iodide + A + H+
-
 ?
3,3',5'-triiodothyronine + AH2 Cavia porcellus
-
 3,3'-diiodothyronine + iodide + A + H+
-
 ?
3,3',5'-triiodothyronine + AH2 Mus musculus
-
 3,3'-diiodothyronine + iodide + A + H+
-
 ?
3,3',5'-triiodothyronine + AH2 Homo sapiens
-
 3,3'-diiodothyronine + iodide + A + H+
-
 ?
3,3',5'-triiodothyronine + AH2 Sus scrofa
-
 3,3'-diiodothyronine + iodide + A + H+
-
 ?
3,3',5'-triiodothyronine + AH2 Bos taurus
-
 3,3'-diiodothyronine + iodide + A + H+
-
 ?
3,3',5'-triiodothyronine + AH2 Ovis aries
-
 3,3'-diiodothyronine + iodide + A + H+
-
 ?
3,3',5'-triiodothyronine + AH2 Rattus sp. isoenzyme type I 3,3'-diiodothyronine + iodide + A + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Cavia porcellus
-
-
-
Gallus gallus
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-
Ovis aries
-
-
-
Rattus sp.
-
 Rattus norvegicus
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Gallus gallus
-
liver
-
 Cavia porcellus
-
liver
-
 Mus musculus
-
liver
-
 Homo sapiens
-
liver
-
 Sus scrofa
-
liver
-
 Bos taurus
-
liver
-
 Ovis aries
-
liver
-
 Rattus sp.
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0001
-
 isoenzyme type I Homo sapiens
0.0001
-
 isoenzyme type I Ovis aries
0.0002
-
 isoenzyme type I Gallus gallus
0.0002
-
 isoenzyme type I Bos taurus
0.0003
-
 isoenzyme type I Sus scrofa
0.0004
-
 isoenzyme type I Mus musculus
0.002
-
 isoenzyme type I Cavia porcellus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,3',5'-triiodothyronine + AH2
-
 Gallus gallus 3,3'-diiodothyronine + iodide + A + H+
-
 ?
3,3',5'-triiodothyronine + AH2
-
 Cavia porcellus 3,3'-diiodothyronine + iodide + A + H+
-
 ?
3,3',5'-triiodothyronine + AH2
-
 Mus musculus 3,3'-diiodothyronine + iodide + A + H+
-
 ?
3,3',5'-triiodothyronine + AH2
-
 Homo sapiens 3,3'-diiodothyronine + iodide + A + H+
-
 ?
3,3',5'-triiodothyronine + AH2
-
 Sus scrofa 3,3'-diiodothyronine + iodide + A + H+
-
 ?
3,3',5'-triiodothyronine + AH2
-
 Bos taurus 3,3'-diiodothyronine + iodide + A + H+
-
 ?
3,3',5'-triiodothyronine + AH2
-
 Ovis aries 3,3'-diiodothyronine + iodide + A + H+
-
 ?
3,3',5'-triiodothyronine + AH2 isoenzyme type I Rattus sp. 3,3'-diiodothyronine + iodide + A + H+
-
 ?

Subunits

Subunits Comment Organism
More substrate binding unit type I Sus scrofa
More substrate binding unit type I 31 kD Homo sapiens
More substrate binding unit type I 29 kD, SDS-PAGE Gallus gallus
More substrate binding unit type I 29 kD, SDS-PAGE Mus musculus
More substrate binding unit type I 29 kD, SDS-PAGE Bos taurus
More substrate binding unit type I 29 kD, SDS-PAGE Ovis aries
More substrate binding unit type I 29 kD, SDS-PAGE Rattus sp.
More substrate binding unit type I 33 kD Cavia porcellus

Synonyms

Synonyms Comment Organism
Iodothyronine 5'-monodeiodinase isoenzyme type I Rattus sp.