Literature summary for 1.21.99.4 extracted from

Burmeister, L.A.; Pachucki, J.; St.Germain, D.L.
Thyroid hormones inhibit type 2 iodothyronine deiodinase in the rat cerebral cortex by both pre- and posttranslational mechanisms (1997), Endocrinology, 138, 5231-5237.

Search for more literature for 1.21.99.4

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	hypothyroidism enhances type II activity and decreases type I activity	Rattus sp.
thyroid hormone L-thyroxine and 3,3',5'-triiodothyronine	type I	Rattus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-thyroxine + AH2	Rattus sp.	-	3,3',5-triiodothyronine + iodide + A + H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus sp.	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	thyronine 5'-deiodinase type II	Rattus sp.	-
brain	isoenzyme D2	Rattus sp.	-
brown adipose tissue	thyronine 5'-deiodinase type II	Rattus sp.	-
hypophysis	thyronine 5'-deiodinase type II	Rattus sp.	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-thyroxine + AH2	-	Rattus sp.	3,3',5-triiodothyronine + iodide + A + H+	-	?

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Release 2023.1 (January 2023)