Activating Compound | Comment | Organism | Structure |
---|---|---|---|
reduced thiols | - |
Rattus sp. | |
reduced thiols | e.g. dithiothreitol | Oncorhynchus mykiss |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-Propyl-2-thiouracil | only type II sensitive to inhibition | Oncorhynchus mykiss | |
6-Propyl-2-thiouracil | - |
Rattus sp. |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.18 | - |
3,3',5'-triiodothyronine | type I, liver | Oncorhynchus mykiss |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,3',5'-triiodothyronine + AH2 | Gallus gallus | - |
3,3'-diiodothyronine + iodide + A + H+ | - |
? | |
3,3',5'-triiodothyronine + AH2 | Oncorhynchus mykiss | isoenzyme type I | 3,3'-diiodothyronine + iodide + A + H+ | - |
? | |
3,3',5'-triiodothyronine + AH2 | Rattus sp. | isoenzyme type I | 3,3'-diiodothyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | Oncorhynchus mykiss | thyronine 5'-deiodinase type II | 3,3',5-triiodothyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | Rattus sp. | thyronine 5'-deiodinase type II | 3,3',5-triiodothyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | Oncorhynchus mykiss | idothyronine 5'-deiodinase type I | 3,3',5'-triiodothyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | Rattus sp. | idothyronine 5'-deiodinase type I | 3,3',5'-triiodothyronine + iodide + A + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus gallus | - |
- |
- |
Lithobates catesbeianus | - |
- |
- |
Oncorhynchus mykiss | - |
- |
- |
Rattus sp. | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | type I and II | Gallus gallus | - |
liver | type II and III | Lithobates catesbeianus | - |
liver | thyronine 5'-deiodinase type I | Oncorhynchus mykiss | - |
liver | thyronine 5'-deiodinase type I | Rattus sp. | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,3',5'-triiodothyronine + AH2 | - |
Gallus gallus | 3,3'-diiodothyronine + iodide + A + H+ | - |
? | |
3,3',5'-triiodothyronine + AH2 | isoenzyme type I | Oncorhynchus mykiss | 3,3'-diiodothyronine + iodide + A + H+ | - |
? | |
3,3',5'-triiodothyronine + AH2 | isoenzyme type I | Rattus sp. | 3,3'-diiodothyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | thyronine 5'-deiodinase type II | Oncorhynchus mykiss | 3,3',5-triiodothyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | thyronine 5'-deiodinase type II | Rattus sp. | 3,3',5-triiodothyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | idothyronine 5'-deiodinase type I | Oncorhynchus mykiss | 3,3',5'-triiodothyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | idothyronine 5'-deiodinase type I | Rattus sp. | 3,3',5'-triiodothyronine + iodide + A + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
iodothyronine 5'-deiodinase | - |
Oncorhynchus mykiss |
iodothyronine 5'-deiodinase | - |
Rattus sp. |
iodothyronine inner ring monodeiodinase | - |
Rattus sp. |
iodothyronine inner ring monodeiodinase | isoenzyme type III | Lithobates catesbeianus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
23 | 25 | - |
Oncorhynchus mykiss |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
- |
Oncorhynchus mykiss |
7 | - |
- |
Rattus sp. |