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Literature summary for 1.21.99.4 extracted from

  • Sharifi, J.; St.Germain, D.L.
    The cDNA for the type I iodothyroine 5'-deiodinase encodes an enzyme manifesting both high KM and low KM activity (1992), J. Biol. Chem., 267, 12539-12544.
    View publication on PubMed
Search for more literature for 1.21.99.4

Activating Compound

Activating Compound Comment Organism Structure
dithiothreitol high concentrations of cofactor increases type I activity Rattus sp.
additional information hypothyroidism enhances type II activity and decreases type I activity Rattus sp.
reduced thiols
-
 Rattus sp.

Cloned(Commentary)

Cloned (Comment) Organism
transcription in vitro, translation in Xenopus laevis oocytes Rattus sp.

Inhibitors

Inhibitors Comment Organism Structure
6-Propyl-2-thiouracil inhibits selectively only thyronine 5'-deiodinase type I activity not type II activity Rattus sp.
ipanoic acid
-
 Rattus sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.1
-
 3,3',5'-triiodothyronine type I Rattus sp.
0.1
-
 3,3',5'-triiodothyronine DTT 20 mM Rattus sp.

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus sp.
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3,3',5'-triiodothyronine + AH2 Rattus sp. isoenzyme type I 3,3'-diiodothyronine + iodide + A + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus sp.
-
-
-

Reaction

Reaction Comment Organism Reaction ID
3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor type II, outer ring (phenolic) deiodination Rattus sp.
a
3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor type I, outer ring (phenolic) deiodination Rattus sp.
a

Source Tissue

Source Tissue Comment Organism Textmining
brain thyronine 5'-deiodinase type II Rattus sp.
-
brown adipose tissue thyronine 5'-deiodinase type II Rattus sp.
-
glial cell thyronine 5'-deiodinase type II Rattus sp.
-
hypophysis thyronine 5'-deiodinase type II Rattus sp.
-
kidney thyronine 5'-deiodinase type I Rattus sp.
-
liver thyronine 5'-deiodinase type I Rattus sp.
-
thyroid gland thyronine 5'-deiodinase type I Rattus sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,3',5'-triiodothyronine + AH2 isoenzyme type I Rattus sp. 3,3'-diiodothyronine + iodide + A + H+
-
 ?

Synonyms

Synonyms Comment Organism
iodothyronine 5'-deiodinase type II, no selenoprotein, induced by bt2cAMP and hydrocortisone (ED50 4nM) Rattus sp.
iodothyronine 5'-deiodinase type I, selenoprotein, inducible by T3 (higher synthesis) and angiotensin II (positive chronotropic effect in myocard) Rattus sp.
iodothyronine 5'-deiodinase isoenzymes type I (D1) and type II (D2) Rattus sp.