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Literature summary for 1.21.99.4 extracted from

  • Leonard, J.L.; Siegrist-Kaiser, C.A.; Zuckerman, C.J.
    Regulation of type II iodothyronine 5'-deiodinase by thyroid hormone (1990), J. Biol. Chem., 265, 940-946.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
thyroid hormone L-thyroxine and 3,3',5'-triiodothyronine extra-nuclear site of action Rattus sp.

General Stability

General Stability Organism
very short lifetime in vivo of isoenzyme type II (D2) from brain Rattus sp.

Inhibitors

Inhibitors Comment Organism Structure
Insulin inhibits enzyme expression in glial cell culture Rattus sp.

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane bound, type II integral in neurolemmal membranes Rattus sp. 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3,3',5'-triiodothyronine + AH2 Rattus sp. isoenzyme type I 3,3'-diiodothyronine + iodide + A + H+
-
?

Organism

Organism UniProt Comment Textmining
Rattus sp.
-
-
-

Reaction

Reaction Comment Organism Reaction ID
3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor type II, outer ring (phenolic) deiodination Rattus sp.

Source Tissue

Source Tissue Comment Organism Textmining
glial cell i.e. brain astrocytes in culture Rattus sp.
-
glial cell measurable activity only during induction with bt2cAMP Rattus sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,3',5'-triiodothyronine + AH2 isoenzyme type I Rattus sp. 3,3'-diiodothyronine + iodide + A + H+
-
?

Synonyms

Synonyms Comment Organism
iodothyronine 5'-deiodinase type II, no selenoprotein, induced by bt2cAMP and hydrocortisone (ED50 4nM) Rattus sp.

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.000467
-
3,3',5'-triiodothyronine
-
Rattus sp.
0.00107
-
3,3',5'-triiodothyronine in hypothyroid medium Rattus sp.