Activating Compound | Comment | Organism | Structure |
---|---|---|---|
thyroid hormone L-thyroxine and 3,3',5'-triiodothyronine | extra-nuclear site of action | Rattus sp. |
General Stability | Organism |
---|---|
very short lifetime in vivo of isoenzyme type II (D2) from brain | Rattus sp. |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Insulin | inhibits enzyme expression in glial cell culture | Rattus sp. |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | bound, type II integral in neurolemmal membranes | Rattus sp. | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,3',5'-triiodothyronine + AH2 | Rattus sp. | isoenzyme type I | 3,3'-diiodothyronine + iodide + A + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus sp. | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor | type II, outer ring (phenolic) deiodination | Rattus sp. |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
glial cell | i.e. brain astrocytes in culture | Rattus sp. | - |
glial cell | measurable activity only during induction with bt2cAMP | Rattus sp. | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,3',5'-triiodothyronine + AH2 | isoenzyme type I | Rattus sp. | 3,3'-diiodothyronine + iodide + A + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
iodothyronine 5'-deiodinase | type II, no selenoprotein, induced by bt2cAMP and hydrocortisone (ED50 4nM) | Rattus sp. |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000467 | - |
3,3',5'-triiodothyronine | - |
Rattus sp. | |
0.00107 | - |
3,3',5'-triiodothyronine | in hypothyroid medium | Rattus sp. |