Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+ | Mus musculus | - |
L-thyroxine + reduced acceptor | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q91ZI8 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
insulinoma cell | - |
Mus musculus | - |
MIN-6 cell | - |
Mus musculus | - |
pancreatic beta cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+ | - |
Mus musculus | L-thyroxine + reduced acceptor | - |
? |
Synonyms | Comment | Organism |
---|---|---|
type 3 iodothyronine deiodinase | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | glucagon-like peptide-1 stimulates type 3 iodothyronine deiodinase expression in Min6 cells in a dose-dependent manner through a GLP-1 receptor-cAMP-PKA-medicated mechanism, and this effect is inhibited by the protein kinase A inhibitor H-89. Exendin-4, a GLP-1 receptor agonist, and forskolin also stimulates type 3 deiodinase expression in MIN6 cells. A cAMP pathway mediates the pretranslational regulation of D3 expression in MIN6 cells | up |
General Information | Comment | Organism |
---|---|---|
metabolism | physiological role of thyroid hormones in the regulation of insulin secretion, overview. type 3 iodothyronine deiodinase-mediated thyroid hormone inactivation is thought to participate in glucose-stimulated insulin secretion from beta cellsA cAMP pathway mediates the pretranslational regulation of D3 expression in MIN6 cells | Mus musculus |
physiological function | type 3 iodothyronine deiodinase (D3) converts thyroxine (T4) and 3,5,3'-triiodothyronine (T3) to3,3',5-triiodothyronine (rT3) and 3,3'-diiodothyronine (T2), respectively, inactivating thyroid hormones in a cell-specific fashion | Mus musculus |