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Literature summary for 1.21.99.3 extracted from

  • Pavelka, S.
    Radiometric enzyme assays: development of methods for extremely sensitive determination of types 1, 2 and 3 iodothyronine deiodinase enzyme activities (2010), J. Radioanal. Nucl. Chem., 286, 861-865.
No PubMed abstract available
Search for more literature for 1.21.99.3

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane integral membrane protein Rattus norvegicus 16020
-
microsome
-
 Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
selenium selenoprotein Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astroglial cell
-
 Rattus norvegicus
-
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,5,3'-triiodo-L-thyronine + AH2
-
 Rattus norvegicus 3,3'-diiodothyronine + iodide + A + H+
-
 ?

Synonyms

Synonyms Comment Organism
type 3 iodothyronine 5-deiodinase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
dithiothreitol
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus incubation (for 8 h at 37°C) of confluent primary cultures of astroglial cells with 0.1 mM ATP causes a 7fold induction of type 3 iodothyronine deiodinase activity. The activity of type 3 iodothyronine deiodinase significantly raises by the influence of 0.001 mM all-trans retinoic acid during preincubation for 2-3 days up