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Literature summary for 1.21.99.3 extracted from

  • Auf dem Brinke, D.; Kohrle, J.; Kodding, R.; Hesch, R.D.
    Subcellular localization of thyroxine-5-deiodinase in rat liver (1980), J. Endocrinol. Invest., 3, 73-76.
    View publication on PubMed
Search for more literature for 1.21.99.3

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome 3,3',5,5'-tetraiodo-L-thyronine-5'-deiodinase and 3,3',5,5'-tetraiodo-L-thyronine-5-deiodinase are solely localized in liver microsomes Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-thyroxine + AH2 Rattus norvegicus 5-deiodinase activity 3,3',5'-triiodo-L-thyronine + iodide + A + H+ from microsomal enzyme complex, 3,3',5'-triiodo-L-thyronine is regulatory active ?
L-thyroxine + AH2 Rattus norvegicus 5'-deiodinase activity 3,3',5-triiodo-L-thyronine + iodide + A + H+ from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor enzyme has both thyroxine 5-deiodinase and thyroxine 5'-deiodinase activities Rattus norvegicus
a

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-thyroxine + AH2 5-deiodinase activity Rattus norvegicus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
L-thyroxine + AH2 5-deiodinase activity Rattus norvegicus 3,3',5'-triiodo-L-thyronine + iodide + A + H+ from microsomal enzyme complex, 3,3',5'-triiodo-L-thyronine is regulatory active ?
L-thyroxine + AH2 5'-deiodinase activity Rattus norvegicus 3,3',5-triiodo-L-thyronine + iodide + A + H+
-
 ?
L-thyroxine + AH2 5'-deiodinase activity Rattus norvegicus 3,3',5-triiodo-L-thyronine + iodide + A + H+ from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active ?

Synonyms

Synonyms Comment Organism
T4-5'-deiodinase
-
 Rattus norvegicus
T4-5-deiodinase
-
 Rattus norvegicus